A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

Yiguang Wang, Kejin Zhou, Gang Huang, Christopher Hensley, Xiaonan Huang, Xinpeng Ma, Tian Zhao, Baran D. Sumer, Ralph J. Deberardinis, Jinming Gao

Research output: Contribution to journalArticle

355 Citations (Scopus)

Abstract

Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug delivery and tissue engineering. For cancer detection, a paramount challenge still exists in the search for methods that can illuminate tumours universally regardless of their genotypes and phenotypes. Here we capitalized on the acidic, angiogenic tumour microenvironment to achieve the detection of tumour tissues in a wide variety of mouse cancer models. This was accomplished using ultra pH-sensitive fluorescent nanoprobes that have tunable, exponential fluorescence activation on encountering subtle, physiologically relevant pH transitions. These nanoprobes were silent in the circulation, and then strongly activated (>300-fold) in response to the neovasculature or to the low extracellular pH in tumours. Thus, we have established non-toxic, fluorescent nanoreporters that can nonlinearly amplify tumour microenvironmental signals, permitting the identification of tumour tissue independently of histological type or driver mutation, and detection of acute treatment responses much more rapidly than conventional imaging approaches.

Original languageEnglish (US)
Pages (from-to)204-212
Number of pages9
JournalNature Materials
Volume13
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Amplification
Tumors
tumors
Nanoparticles
Imaging techniques
nanoparticles
Nanoprobes
cancer
Tissue
Molecular imaging
phenotype
tissue engineering
mutations
Drug delivery
Tissue engineering
Nanostructured materials
stimuli
mice
delivery
drugs

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. / Wang, Yiguang; Zhou, Kejin; Huang, Gang; Hensley, Christopher; Huang, Xiaonan; Ma, Xinpeng; Zhao, Tian; Sumer, Baran D.; Deberardinis, Ralph J.; Gao, Jinming.

In: Nature Materials, Vol. 13, No. 2, 02.2014, p. 204-212.

Research output: Contribution to journalArticle

@article{4fdabed40c314db6b7c40e3b53bf72d2,
title = "A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals",
abstract = "Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug delivery and tissue engineering. For cancer detection, a paramount challenge still exists in the search for methods that can illuminate tumours universally regardless of their genotypes and phenotypes. Here we capitalized on the acidic, angiogenic tumour microenvironment to achieve the detection of tumour tissues in a wide variety of mouse cancer models. This was accomplished using ultra pH-sensitive fluorescent nanoprobes that have tunable, exponential fluorescence activation on encountering subtle, physiologically relevant pH transitions. These nanoprobes were silent in the circulation, and then strongly activated (>300-fold) in response to the neovasculature or to the low extracellular pH in tumours. Thus, we have established non-toxic, fluorescent nanoreporters that can nonlinearly amplify tumour microenvironmental signals, permitting the identification of tumour tissue independently of histological type or driver mutation, and detection of acute treatment responses much more rapidly than conventional imaging approaches.",
author = "Yiguang Wang and Kejin Zhou and Gang Huang and Christopher Hensley and Xiaonan Huang and Xinpeng Ma and Tian Zhao and Sumer, {Baran D.} and Deberardinis, {Ralph J.} and Jinming Gao",
year = "2014",
month = "2",
doi = "10.1038/nmat3819",
language = "English (US)",
volume = "13",
pages = "204--212",
journal = "Nature Materials",
issn = "1476-1122",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

AU - Wang, Yiguang

AU - Zhou, Kejin

AU - Huang, Gang

AU - Hensley, Christopher

AU - Huang, Xiaonan

AU - Ma, Xinpeng

AU - Zhao, Tian

AU - Sumer, Baran D.

AU - Deberardinis, Ralph J.

AU - Gao, Jinming

PY - 2014/2

Y1 - 2014/2

N2 - Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug delivery and tissue engineering. For cancer detection, a paramount challenge still exists in the search for methods that can illuminate tumours universally regardless of their genotypes and phenotypes. Here we capitalized on the acidic, angiogenic tumour microenvironment to achieve the detection of tumour tissues in a wide variety of mouse cancer models. This was accomplished using ultra pH-sensitive fluorescent nanoprobes that have tunable, exponential fluorescence activation on encountering subtle, physiologically relevant pH transitions. These nanoprobes were silent in the circulation, and then strongly activated (>300-fold) in response to the neovasculature or to the low extracellular pH in tumours. Thus, we have established non-toxic, fluorescent nanoreporters that can nonlinearly amplify tumour microenvironmental signals, permitting the identification of tumour tissue independently of histological type or driver mutation, and detection of acute treatment responses much more rapidly than conventional imaging approaches.

AB - Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug delivery and tissue engineering. For cancer detection, a paramount challenge still exists in the search for methods that can illuminate tumours universally regardless of their genotypes and phenotypes. Here we capitalized on the acidic, angiogenic tumour microenvironment to achieve the detection of tumour tissues in a wide variety of mouse cancer models. This was accomplished using ultra pH-sensitive fluorescent nanoprobes that have tunable, exponential fluorescence activation on encountering subtle, physiologically relevant pH transitions. These nanoprobes were silent in the circulation, and then strongly activated (>300-fold) in response to the neovasculature or to the low extracellular pH in tumours. Thus, we have established non-toxic, fluorescent nanoreporters that can nonlinearly amplify tumour microenvironmental signals, permitting the identification of tumour tissue independently of histological type or driver mutation, and detection of acute treatment responses much more rapidly than conventional imaging approaches.

UR - http://www.scopus.com/inward/record.url?scp=84892980829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892980829&partnerID=8YFLogxK

U2 - 10.1038/nmat3819

DO - 10.1038/nmat3819

M3 - Article

VL - 13

SP - 204

EP - 212

JO - Nature Materials

JF - Nature Materials

SN - 1476-1122

IS - 2

ER -