A naphthalimide fluorescent sensor for Zn2+ based on photo-induced electron transfer

Jiangli Fan; Yunkou Wu; Xiaojun Peng

doi:10.1246/cl.2004.1392

A naphthalimide fluorescent sensor for Zn²⁺ based on photo-induced electron transfer

Jiangli Fan, Yunkou Wu, Xiaojun Peng

Advanced Imaging Research Center

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A new Zn²⁺ fluorescent sensor NIDPA (1) which takes 1,8-naphthalimide as a reporting group and di-2-picolylamine (DPA) as a recognizing group has been synthesized via simple steps. Based on photo-induced electron transfer (PET) mechanism, NIDPA has a nearly 5-fold fluorescent enhancement under simulated physiological conditions corresponding to the binding of Zn²⁺. Apparent dissociation constant for Zn²⁺ (K_d) is in the sub-nM range, and Ca²⁺, Mg²⁺, Fe³⁺, Ni²⁺, and Cr³⁺ have little influence on fluorescence enhancement.

Original language	English (US)
Article number	CL-040809
Pages (from-to)	1392-1393
Number of pages	2
Journal	Chemistry Letters
Volume	33
Issue number	10
DOIs	https://doi.org/10.1246/cl.2004.1392
State	Published - Oct 5 2004

ASJC Scopus subject areas

General Chemistry

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10.1246/cl.2004.1392

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abstract = "A new Zn2+ fluorescent sensor NIDPA (1) which takes 1,8-naphthalimide as a reporting group and di-2-picolylamine (DPA) as a recognizing group has been synthesized via simple steps. Based on photo-induced electron transfer (PET) mechanism, NIDPA has a nearly 5-fold fluorescent enhancement under simulated physiological conditions corresponding to the binding of Zn2+. Apparent dissociation constant for Zn2+ (Kd) is in the sub-nM range, and Ca2+, Mg2+, Fe3+, Ni2+, and Cr3+ have little influence on fluorescence enhancement.",

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A naphthalimide fluorescent sensor for Zn²⁺ based on photo-induced electron transfer

Abstract

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