A national study of helicobactor pylori infection in gastric biopsy specimens

Amnon Sonnenberg, Richard H. Lash, Robert M. Genta

Research output: Contribution to journalArticle

131 Scopus citations

Abstract

Background & Aims We investigated whether infection with Helicobacter pylori and signs of chronic active gastritis and intestinal metaplasia in gastric biopsy samples were inversely associated with Barrett's metaplasia. Methods We studied gastric biopsy samples from 78,985 unique patients. Histologic findings were correlated with sociodemographic patient characteristics using multivariate logistic regression to calculate odds ratios and 95% confidence intervals. Results H pylori infection, chronic active gastritis, and intestinal metaplasia had similar epidemiologic patterns. The presence of each, based on histology analyses, was significantly associated with that of the others. They were also characterized by similar geographic distributions within the United States. All 3 disorders were more common among men and among Medicaid patients (compared with those with other insurance) and were inversely associated with Barrett's metaplasia (less frequent in patients with Barrett's metaplasia). Conclusions H pylori infection and associated disorders, such as chronic active gastritis and intestinal metaplasia, are inversely associated with Barrett's metaplasia.

Original languageEnglish (US)
Pages (from-to)1894-1901.e2
JournalGastroenterology
Volume139
Issue number6
DOIs
StatePublished - Dec 2010

Keywords

  • Barretts Esophagus
  • Epidemiology of Gastritis
  • Gastrointestinal Microbes
  • Stomach Cancer

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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