A neural pathway controlling motivation to exert effort

Christophe D. Proulx, Sage Aronson, Djordje Milivojevic, Cris Molina, Alan Loi, Bradley Monk, Steven J. Shabel, Roberto Malinow

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The neural mechanisms conferring reduced motivation, as observed in depressed individuals, is poorly understood. Here, we examine in rodents if reduced motivation to exert effort is controlled by transmission from the lateral habenula (LHb), a nucleus overactive in depressed-like states, to the rostromedial tegmental nucleus (RMTg), a nucleus that inhibits dopaminergic neurons. In an aversive test wherein immobility indicates loss of effort, LHb→RMTg transmission increased during transitions into immobility, driving LHb→RMTg increased immobility, and inhibiting LHb→RMTg produced the opposite effects. In an appetitive test, driving LHb→RMTg reduced the effort exerted to receive a reward, without affecting the reward’s hedonic property. Notably, LHb→RMTg stimulation only affected specific aspects of these motor tasks, did not affect all motor tasks, and promoted avoidance, indicating that LHb→RMTg activity does not generally reduce movement but appears to carry a negative valence that reduces effort. These results indicate that LHb→RMTg activity controls the motivation to exert effort and may contribute to the reduced motivation in depression.

Original languageEnglish (US)
Pages (from-to)5792-5797
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number22
DOIs
StatePublished - May 29 2018

Fingerprint

Neural Pathways
Motivation
Reward
Habenula
Pleasure
Dopaminergic Neurons
Rodentia
Depression

Keywords

  • Fiber photometry
  • Lateral habenula
  • Motivation
  • Optogenetics
  • Rostromedial tegmental nucleus

ASJC Scopus subject areas

  • General

Cite this

Proulx, C. D., Aronson, S., Milivojevic, D., Molina, C., Loi, A., Monk, B., ... Malinow, R. (2018). A neural pathway controlling motivation to exert effort. Proceedings of the National Academy of Sciences of the United States of America, 115(22), 5792-5797. https://doi.org/10.1073/pnas.1801837115

A neural pathway controlling motivation to exert effort. / Proulx, Christophe D.; Aronson, Sage; Milivojevic, Djordje; Molina, Cris; Loi, Alan; Monk, Bradley; Shabel, Steven J.; Malinow, Roberto.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 22, 29.05.2018, p. 5792-5797.

Research output: Contribution to journalArticle

Proulx, CD, Aronson, S, Milivojevic, D, Molina, C, Loi, A, Monk, B, Shabel, SJ & Malinow, R 2018, 'A neural pathway controlling motivation to exert effort', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. 5792-5797. https://doi.org/10.1073/pnas.1801837115
Proulx, Christophe D. ; Aronson, Sage ; Milivojevic, Djordje ; Molina, Cris ; Loi, Alan ; Monk, Bradley ; Shabel, Steven J. ; Malinow, Roberto. / A neural pathway controlling motivation to exert effort. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 22. pp. 5792-5797.
@article{35815bfa44cf479087de8212df7e4f89,
title = "A neural pathway controlling motivation to exert effort",
abstract = "The neural mechanisms conferring reduced motivation, as observed in depressed individuals, is poorly understood. Here, we examine in rodents if reduced motivation to exert effort is controlled by transmission from the lateral habenula (LHb), a nucleus overactive in depressed-like states, to the rostromedial tegmental nucleus (RMTg), a nucleus that inhibits dopaminergic neurons. In an aversive test wherein immobility indicates loss of effort, LHb→RMTg transmission increased during transitions into immobility, driving LHb→RMTg increased immobility, and inhibiting LHb→RMTg produced the opposite effects. In an appetitive test, driving LHb→RMTg reduced the effort exerted to receive a reward, without affecting the reward’s hedonic property. Notably, LHb→RMTg stimulation only affected specific aspects of these motor tasks, did not affect all motor tasks, and promoted avoidance, indicating that LHb→RMTg activity does not generally reduce movement but appears to carry a negative valence that reduces effort. These results indicate that LHb→RMTg activity controls the motivation to exert effort and may contribute to the reduced motivation in depression.",
keywords = "Fiber photometry, Lateral habenula, Motivation, Optogenetics, Rostromedial tegmental nucleus",
author = "Proulx, {Christophe D.} and Sage Aronson and Djordje Milivojevic and Cris Molina and Alan Loi and Bradley Monk and Shabel, {Steven J.} and Roberto Malinow",
year = "2018",
month = "5",
day = "29",
doi = "10.1073/pnas.1801837115",
language = "English (US)",
volume = "115",
pages = "5792--5797",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "22",

}

TY - JOUR

T1 - A neural pathway controlling motivation to exert effort

AU - Proulx, Christophe D.

AU - Aronson, Sage

AU - Milivojevic, Djordje

AU - Molina, Cris

AU - Loi, Alan

AU - Monk, Bradley

AU - Shabel, Steven J.

AU - Malinow, Roberto

PY - 2018/5/29

Y1 - 2018/5/29

N2 - The neural mechanisms conferring reduced motivation, as observed in depressed individuals, is poorly understood. Here, we examine in rodents if reduced motivation to exert effort is controlled by transmission from the lateral habenula (LHb), a nucleus overactive in depressed-like states, to the rostromedial tegmental nucleus (RMTg), a nucleus that inhibits dopaminergic neurons. In an aversive test wherein immobility indicates loss of effort, LHb→RMTg transmission increased during transitions into immobility, driving LHb→RMTg increased immobility, and inhibiting LHb→RMTg produced the opposite effects. In an appetitive test, driving LHb→RMTg reduced the effort exerted to receive a reward, without affecting the reward’s hedonic property. Notably, LHb→RMTg stimulation only affected specific aspects of these motor tasks, did not affect all motor tasks, and promoted avoidance, indicating that LHb→RMTg activity does not generally reduce movement but appears to carry a negative valence that reduces effort. These results indicate that LHb→RMTg activity controls the motivation to exert effort and may contribute to the reduced motivation in depression.

AB - The neural mechanisms conferring reduced motivation, as observed in depressed individuals, is poorly understood. Here, we examine in rodents if reduced motivation to exert effort is controlled by transmission from the lateral habenula (LHb), a nucleus overactive in depressed-like states, to the rostromedial tegmental nucleus (RMTg), a nucleus that inhibits dopaminergic neurons. In an aversive test wherein immobility indicates loss of effort, LHb→RMTg transmission increased during transitions into immobility, driving LHb→RMTg increased immobility, and inhibiting LHb→RMTg produced the opposite effects. In an appetitive test, driving LHb→RMTg reduced the effort exerted to receive a reward, without affecting the reward’s hedonic property. Notably, LHb→RMTg stimulation only affected specific aspects of these motor tasks, did not affect all motor tasks, and promoted avoidance, indicating that LHb→RMTg activity does not generally reduce movement but appears to carry a negative valence that reduces effort. These results indicate that LHb→RMTg activity controls the motivation to exert effort and may contribute to the reduced motivation in depression.

KW - Fiber photometry

KW - Lateral habenula

KW - Motivation

KW - Optogenetics

KW - Rostromedial tegmental nucleus

UR - http://www.scopus.com/inward/record.url?scp=85047897115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047897115&partnerID=8YFLogxK

U2 - 10.1073/pnas.1801837115

DO - 10.1073/pnas.1801837115

M3 - Article

C2 - 29752382

AN - SCOPUS:85047897115

VL - 115

SP - 5792

EP - 5797

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 22

ER -