A new biology of diabetes revealed by leptin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a pathway that protects nonadipose tissues from overaccumulation of potentially toxic lipids and unrecognized paracrine interactions between α and β cells revealed by leptin's ability to suppress diabetic hyperglucagonemia. These observations strongly point to new therapeutic possibilities for both type 1 and type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalCell Metabolism
Volume21
Issue number1
DOIs
StatePublished - Jan 6 2015

Fingerprint

Leptin
Poisons
Metabolic Diseases
Type 1 Diabetes Mellitus
Cell Communication
Type 2 Diabetes Mellitus
Lipids
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

A new biology of diabetes revealed by leptin. / Unger, Roger H; Roth, Michael G.

In: Cell Metabolism, Vol. 21, No. 1, 06.01.2015, p. 15-20.

Research output: Contribution to journalArticle

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