A new F-18 labeled PET agent for imaging Alzheimer's plaques

Padmakar V. Kulkarni, Neil Vasdev, Guiyang Hao, Veera Arora, Michael Long, Nikolai Slavine, Srinivas Chiguru, Bao Xi Qu, Xiankai Sun, Michael Bennett, Peter P. Antich, Frederick J. Bonte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD). Advances in development of imaging agents have focused on targeting amyloid plaques. Notable success has been the development of C-11 labeled PIB (Pittsburgh Compound) and a number of studies have demonstrated the utility of this agent. However, the short half life of C-11 (t1/2: 20 min), is a limitation, thus has prompted the development of F-18 labeled agents. Most of these agents are derivatives of amyloid binding dyes; Congo red and Thioflavin. Some of these agents are in clinical trials with encouraging results. We have been exploring new class of agents based on 8-hydroxy quinoline, a weak metal chelator, targeting elevated levels of metals in plaques. Iodine-123 labeled clioquinol showed affinity for amyloid plaques however, it had limited brain uptake and was not successful in imaging in intact animals and humans. We have been successful in synthesizing F-18 labeled 8-hydroxy quinoline. Small animal PET/CT imaging studies with this agent showed high (7-10% ID/g), rapid brain uptake and fast washout of the agent from normal mice brains and delayed washout from transgenic Alzheimer's mice. These promising results encouraged us in further evaluation of this class of compounds for imaging AD plaques.

Original languageEnglish (US)
Title of host publicationApplication of Accelerators in Research and Industry - Twenty-First International Conference, CAARI 2010
Pages383-385
Number of pages3
DOIs
StatePublished - Jul 14 2011
Event21st International Conference on Application of Accelerators in Research and Industry, CAARI 2010 - Fort Worth, TX, United States
Duration: Aug 8 2010Aug 13 2010

Publication series

NameAIP Conference Proceedings
Volume1336
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other21st International Conference on Application of Accelerators in Research and Industry, CAARI 2010
CountryUnited States
CityFort Worth, TX
Period8/8/108/13/10

Keywords

  • Alzheimer's disease
  • Amyloid
  • Animal model
  • PET imaging
  • Quinoline

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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