A new H-2-linked class I gene whose expression depends on a maternally inherited factor

Kirsten Fischer Lindahl, Barbara Hausmann, Verne M. Chapman

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The maternally transmitted antigen (Mta) is expressed on the cells of most strains of mice1,2. It is a medial histocompatibility antigen 3, that is, it is recognized by unrestricted cytotoxic T lymphocytes as are major H antigens, but unlike these it is a weak transplantation antigen and does not itself restrict the T-cell recognition of minor H antigens. All other medial H antigens are encoded by genes closely linked to the major histocompatibility complex3, H-2 in the mouse. By contrast, Mta appeared to follow extrachromosomal, maternal inheritance. Several substrains of NZB, NZO and non-inbred European NMRI mice are Mta-negative. Females of these strains bear only Mta- offspring, while females of the inbred Mta+ strains bear only Mta+ offspring. Repeated backcrossing from Mta+ females to NZB or NMRI males has shown that, given the right cytoplasmic genes, the chromosomal genes of these Mta - strains permit expression of Mta2. As the Mta type of a mouse cannot be influenced by embryo transfer or foster nursing2,4, we concluded that it was determined by a cytoplasmic factor (Mtf), transmitted through the egg. We now show that a gene, Hmt, closely linked to the H-2 complex, is also required for expression of Mta.

Original languageEnglish (US)
Pages (from-to)383-385
Number of pages3
JournalNature
Volume306
Issue number5941
DOIs
StatePublished - 1983

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MHC Class I Genes
Gene Expression
Antigens
Histocompatibility Antigens
Genes
Extrachromosomal Inheritance
Histocompatibility
Inbreeding
Maternal Inheritance
Embryo Transfer
Cytotoxic T-Lymphocytes
Ovum
T-Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

A new H-2-linked class I gene whose expression depends on a maternally inherited factor. / Lindahl, Kirsten Fischer; Hausmann, Barbara; Chapman, Verne M.

In: Nature, Vol. 306, No. 5941, 1983, p. 383-385.

Research output: Contribution to journalArticle

Lindahl, KF, Hausmann, B & Chapman, VM 1983, 'A new H-2-linked class I gene whose expression depends on a maternally inherited factor', Nature, vol. 306, no. 5941, pp. 383-385. https://doi.org/10.1038/306383a0
Lindahl, Kirsten Fischer ; Hausmann, Barbara ; Chapman, Verne M. / A new H-2-linked class I gene whose expression depends on a maternally inherited factor. In: Nature. 1983 ; Vol. 306, No. 5941. pp. 383-385.
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