A new method for radiochemical separation of arsenic from irradiated germanium oxide

M. Jennewein, S. M. Qaim, A. Hermanne, M. Jahn, E. Tsyganov, N. Slavine, S. Seliounine, P. A. Antich, P. V. Kulkarni, P. E. Thorpe, R. P. Mason, F. Rösch

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Abstract

Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of 72As (T1/2=26 h) and 74As (T1/2=17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes*As, with*=71, 72, 73, 74 or 77, the reaction to [*As]AsI3 and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as [GeF6]2-. [*As]AsI3 is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI 3 is a versatile radioarsenic labelling synthon.

Original languageEnglish (US)
Pages (from-to)343-351
Number of pages9
JournalApplied Radiation and Isotopes
Volume63
Issue number3
DOIs
Publication statusPublished - Sep 2005

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Keywords

  • As-71
  • As-72
  • As-73
  • As-74
  • As-77
  • Radiochemical separation
  • Solid-phase extraction

ASJC Scopus subject areas

  • Radiation

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