A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B

Amos B. Smith, László Kürti, Akin H. Davulcu

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Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns.

Original languageEnglish (US)
Pages (from-to)2167-2170
Number of pages4
JournalOrganic Letters
Issue number10
Publication statusPublished - May 11 2006


ASJC Scopus subject areas

  • Molecular Medicine

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