Abstract
Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns.
Original language | English (US) |
---|---|
Pages (from-to) | 2167-2170 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 10 |
DOIs | |
State | Published - May 11 2006 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry