A new PET fluorescent sensor for Zn2+

Jiangli Fan; Xiaojun Peng; Yunkou Wu; Erhu Lu; Jun Hou; Hongbing Zhang; Rong Zhang; Xinmei Fu

doi:10.1016/j.jlumin.2004.12.008

A new PET fluorescent sensor for Zn²⁺

Jiangli Fan, Xiaojun Peng, Yunkou Wu, Erhu Lu, Jun Hou, Hongbing Zhang, Rong Zhang, Xinmei Fu

Advanced Imaging Research Center

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A new Zn²⁺ fluorescent sensor NIDPA, with 1,8-naphthalimide as reporting group and di-2-picolylamine (DPA) as recognizing group, has been synthesized via simple steps. Based on photo-induced electron transfer (PET) mechanism, NIDPA has a five-fold fluorescent enhancement and 10 nm absorption blue-shift under simulated physiological conditions corresponding to the binding of Zn²⁺. Apparent dissociation constant for Zn²⁺ (K_d) is 0.83 nM, and Ca²⁺, Mg²⁺, Fe ²⁺, Ni²⁺ and Cr³⁺have little influence on fluorescent enhancement. These results suggest that NIDPA can be used to quantitatively and selectively measure the concentration of Zn²⁺ around sub-nanomolar range.

Original language	English (US)
Pages (from-to)	125-130
Number of pages	6
Journal	Journal of Luminescence
Volume	114
Issue number	2
DOIs	https://doi.org/10.1016/j.jlumin.2004.12.008
State	Published - Aug 2005

Keywords

1,8-naphthalimide
Fluorescent probe
Fluorescent sensors
PET
Zinc ion

ASJC Scopus subject areas

Biophysics
Biochemistry
General Chemistry
Atomic and Molecular Physics, and Optics
Condensed Matter Physics

Access to Document

10.1016/j.jlumin.2004.12.008

Cite this

@article{4e1a1415e50a43a0bab095940b10b51f,

title = "A new PET fluorescent sensor for Zn2+",

abstract = "A new Zn2+ fluorescent sensor NIDPA, with 1,8-naphthalimide as reporting group and di-2-picolylamine (DPA) as recognizing group, has been synthesized via simple steps. Based on photo-induced electron transfer (PET) mechanism, NIDPA has a five-fold fluorescent enhancement and 10 nm absorption blue-shift under simulated physiological conditions corresponding to the binding of Zn2+. Apparent dissociation constant for Zn2+ (Kd) is 0.83 nM, and Ca2+, Mg2+, Fe 2+, Ni2+ and Cr3+have little influence on fluorescent enhancement. These results suggest that NIDPA can be used to quantitatively and selectively measure the concentration of Zn2+ around sub-nanomolar range.",

keywords = "1,8-naphthalimide, Fluorescent probe, Fluorescent sensors, PET, Zinc ion",

author = "Jiangli Fan and Xiaojun Peng and Yunkou Wu and Erhu Lu and Jun Hou and Hongbing Zhang and Rong Zhang and Xinmei Fu",

note = "Funding Information: This work was supported by “973 program” of the Ministry of Science and Technology of China and the National Science Foundation of China (Projects 20128005, 20376010 and 20472012).",

year = "2005",

month = aug,

doi = "10.1016/j.jlumin.2004.12.008",

language = "English (US)",

volume = "114",

pages = "125--130",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier",

number = "2",

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T1 - A new PET fluorescent sensor for Zn2+

AU - Fan, Jiangli

AU - Peng, Xiaojun

AU - Wu, Yunkou

AU - Lu, Erhu

AU - Hou, Jun

AU - Zhang, Hongbing

AU - Zhang, Rong

AU - Fu, Xinmei

N1 - Funding Information: This work was supported by “973 program” of the Ministry of Science and Technology of China and the National Science Foundation of China (Projects 20128005, 20376010 and 20472012).

PY - 2005/8

Y1 - 2005/8

N2 - A new Zn2+ fluorescent sensor NIDPA, with 1,8-naphthalimide as reporting group and di-2-picolylamine (DPA) as recognizing group, has been synthesized via simple steps. Based on photo-induced electron transfer (PET) mechanism, NIDPA has a five-fold fluorescent enhancement and 10 nm absorption blue-shift under simulated physiological conditions corresponding to the binding of Zn2+. Apparent dissociation constant for Zn2+ (Kd) is 0.83 nM, and Ca2+, Mg2+, Fe 2+, Ni2+ and Cr3+have little influence on fluorescent enhancement. These results suggest that NIDPA can be used to quantitatively and selectively measure the concentration of Zn2+ around sub-nanomolar range.

AB - A new Zn2+ fluorescent sensor NIDPA, with 1,8-naphthalimide as reporting group and di-2-picolylamine (DPA) as recognizing group, has been synthesized via simple steps. Based on photo-induced electron transfer (PET) mechanism, NIDPA has a five-fold fluorescent enhancement and 10 nm absorption blue-shift under simulated physiological conditions corresponding to the binding of Zn2+. Apparent dissociation constant for Zn2+ (Kd) is 0.83 nM, and Ca2+, Mg2+, Fe 2+, Ni2+ and Cr3+have little influence on fluorescent enhancement. These results suggest that NIDPA can be used to quantitatively and selectively measure the concentration of Zn2+ around sub-nanomolar range.

KW - 1,8-naphthalimide

KW - Fluorescent probe

KW - Fluorescent sensors

KW - PET

KW - Zinc ion

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