A novel ALK rearrangement in an inflammatory myofibroblastic tumor in a neonate

Nicci Owusu-Brackett, Romaine Johnson, David T. Schindel, Prasad Koduru, Sandy Cope-Yokoyama

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Inflammatory myofibroblastic tumors (IMTs) are uncommon lesions primarily affecting children and young adults. They have rarely been described in infants, with a very small number described in neonates. Structural rearrangements in the anaplastic large-cell lymphoma kinase gene (ALK) has contributed to our categorizing this lesion as a neoplasm. In addition, rearrangements of the ALK gene have been implicated in the pathogenicity of many other hematolymphoid and nonhematolymphoid tumors, typically involving 2p23 with different partners or with pericentric inversion. We report a previously undescribed cryptic deletion and intrachromosomal-insertional translocation of the 3'-region of the ALK gene from 2p23 to the 2q33-q35 in an IMT of a newborn patient with an apparently normal G-band karyotype of the tumor.

Original languageEnglish (US)
Pages (from-to)353-356
Number of pages4
JournalCancer Genetics
Volume206
Issue number9-10
DOIs
StatePublished - Sep 1 2013

Keywords

  • ALK
  • EXIT procedure
  • Inflammatory myofibroblastic tumor
  • Neonate
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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