A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3

Muhammad Aslam, Muhammad Wajid, Maria H. Chahrour, Muhammad Ansar, Sayedul Haque, Thanh L. Pham, Regie P. Santos, Kai Yan, Wasim Ahmad, Suzanne M. Leal

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13 Scopus citations

Abstract

A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume133 A
Issue number1
DOIs
StatePublished - Feb 15 2005

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Keywords

  • 3q13.31-q22.3
  • DFNB42
  • Nonsyndromic hearing impairment
  • Pakistan

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Aslam, M., Wajid, M., Chahrour, M. H., Ansar, M., Haque, S., Pham, T. L., Santos, R. P., Yan, K., Ahmad, W., & Leal, S. M. (2005). A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3. American Journal of Medical Genetics, 133 A(1), 18-22. https://doi.org/10.1002/ajmg.a.30508