A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3

Muhammad Aslam, Muhammad Wajid, Maria H. Chahrour, Muhammad Ansar, Sayedul Haque, Thanh L. Pham, Regie P. Santos, Kai Yan, Wasim Ahmad, Suzanne M. Leal

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume133 A
Issue number1
DOIs
StatePublished - Feb 15 2005

Fingerprint

Chromosomes
Chromosomes, Human, Pair 3
Pakistan
Nonsyndromic Deafness
Autosomal Recessive 42 Deafness

Keywords

  • 3q13.31-q22.3
  • DFNB42
  • Nonsyndromic hearing impairment
  • Pakistan

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3. / Aslam, Muhammad; Wajid, Muhammad; Chahrour, Maria H.; Ansar, Muhammad; Haque, Sayedul; Pham, Thanh L.; Santos, Regie P.; Yan, Kai; Ahmad, Wasim; Leal, Suzanne M.

In: American Journal of Medical Genetics, Vol. 133 A, No. 1, 15.02.2005, p. 18-22.

Research output: Contribution to journalArticle

Aslam, M, Wajid, M, Chahrour, MH, Ansar, M, Haque, S, Pham, TL, Santos, RP, Yan, K, Ahmad, W & Leal, SM 2005, 'A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3', American Journal of Medical Genetics, vol. 133 A, no. 1, pp. 18-22. https://doi.org/10.1002/ajmg.a.30508
Aslam, Muhammad ; Wajid, Muhammad ; Chahrour, Maria H. ; Ansar, Muhammad ; Haque, Sayedul ; Pham, Thanh L. ; Santos, Regie P. ; Yan, Kai ; Ahmad, Wasim ; Leal, Suzanne M. / A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3. In: American Journal of Medical Genetics. 2005 ; Vol. 133 A, No. 1. pp. 18-22.
@article{385074489e8340b1ae687290eb53b94c,
title = "A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3",
abstract = "A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.",
keywords = "3q13.31-q22.3, DFNB42, Nonsyndromic hearing impairment, Pakistan",
author = "Muhammad Aslam and Muhammad Wajid and Chahrour, {Maria H.} and Muhammad Ansar and Sayedul Haque and Pham, {Thanh L.} and Santos, {Regie P.} and Kai Yan and Wasim Ahmad and Leal, {Suzanne M.}",
year = "2005",
month = "2",
day = "15",
doi = "10.1002/ajmg.a.30508",
language = "English (US)",
volume = "133 A",
pages = "18--22",
journal = "American Journal of Medical Genetics, Part A",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3

AU - Aslam, Muhammad

AU - Wajid, Muhammad

AU - Chahrour, Maria H.

AU - Ansar, Muhammad

AU - Haque, Sayedul

AU - Pham, Thanh L.

AU - Santos, Regie P.

AU - Yan, Kai

AU - Ahmad, Wasim

AU - Leal, Suzanne M.

PY - 2005/2/15

Y1 - 2005/2/15

N2 - A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.

AB - A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.

KW - 3q13.31-q22.3

KW - DFNB42

KW - Nonsyndromic hearing impairment

KW - Pakistan

UR - http://www.scopus.com/inward/record.url?scp=19944430504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944430504&partnerID=8YFLogxK

U2 - 10.1002/ajmg.a.30508

DO - 10.1002/ajmg.a.30508

M3 - Article

VL - 133 A

SP - 18

EP - 22

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 1552-4825

IS - 1

ER -