A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes

Manisha Deshpande, K. Venuprasad, Pradeep B. Parab, Bhaskar Saha, Debashis Mitra

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The primary transcript of the human CD28 gene in T lymphocytes, encoding for a costimulatory molecule, is known to undergo alternative splicing, and different small sets of variant isoforms have been reported. This report presents the novel simultaneous presence of eight different mRNA isoforms, all observed together in normal human T cells; this is an interesting finding in the study of CD28 mRNA structural variants. A similar pattern was found in a total of four individuals. In addition, we also report the occurence and sequence of a new CD28 mRNA isoform, one of the above eight, which is a novel variant generated by the use of a new combination of splice donor and acceptor sites.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalHuman Immunology
Volume63
Issue number1
DOIs
StatePublished - Jan 29 2002

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Keywords

  • Alternative splicing
  • CD28
  • Human
  • Isoforms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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