A novel class of polymeric pH-responsive MRI CEST agents

Shanrong Zhang, Kejin Zhou, Gang Huang, Masaya Takahashi, A. Dean Sherry, Jinming Gao

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment.

Original languageEnglish (US)
Pages (from-to)6418-6420
Number of pages3
JournalChemical Communications
Volume49
Issue number57
DOIs
StatePublished - Jul 21 2013

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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