A novel class of polymeric pH-responsive MRI CEST agents

Shanrong Zhang; Kejin Zhou; Gang Huang; Masaya Takahashi; A. Dean Sherry; Jinming Gao

doi:10.1039/c3cc42452a

A novel class of polymeric pH-responsive MRI CEST agents

Shanrong Zhang, Kejin Zhou, Gang Huang, Masaya Takahashi, A. Dean Sherry, Jinming Gao

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially “off” when the polymers form micelles near physiological pH but is activated to the “on” state when the micelles dissociate in an acidic environment.

Original language	English (US)
Pages (from-to)	6418-6420
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	57
DOIs	https://doi.org/10.1039/c3cc42452a
State	Published - Jun 20 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "A novel class of polymeric pH-responsive MRI CEST agents",

abstract = "In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially “off” when the polymers form micelles near physiological pH but is activated to the “on” state when the micelles dissociate in an acidic environment.",

author = "Shanrong Zhang and Kejin Zhou and Gang Huang and Masaya Takahashi and {Dean Sherry}, A. and Jinming Gao",

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AU - Huang, Gang

AU - Takahashi, Masaya

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AU - Gao, Jinming

PY - 2013/6/20

Y1 - 2013/6/20

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AB - In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially “off” when the polymers form micelles near physiological pH but is activated to the “on” state when the micelles dissociate in an acidic environment.

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A novel class of polymeric pH-responsive MRI CEST agents

Abstract

ASJC Scopus subject areas

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