Abstract

In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment.

Original languageEnglish (US)
Pages (from-to)6418-6420
Number of pages3
JournalChemical Communications
Volume49
Issue number57
DOIs
StatePublished - Jul 21 2013

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Micelles
Magnetic resonance
Imaging techniques
Contrast Media
Block copolymers
Amines
Polymers
Communication

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

A novel class of polymeric pH-responsive MRI CEST agents. / Zhang, Shanrong; Zhou, Kejin; Huang, Gang; Takahashi, Masaya; Dean Sherry, A.; Gao, Jinming.

In: Chemical Communications, Vol. 49, No. 57, 21.07.2013, p. 6418-6420.

Research output: Contribution to journalArticle

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