Abstract
A novel technique is proposed to facilitate the selective imaging of specific molecules from a mixture. The application of the technique presented here demonstrates the ability to selectively produce 19F MR images of either trifluoroacetic acid or the perfluorocarbon emulsion Oxypherol-ET (perfluorotributylamine), when both molecules are present simultaneously. Selective detection is based on the presence of homonuclear J-modulation in one molecule and differential spin-spin relaxation time (T2). Perfluorotributylamine, an A3B2 system, is subject to homonuclear J-modulation, which produces a null signal from the antiphase components of the triplet (A3) when an echo time (TE) = 1 2J is used in a spin-echo image. At this echo time the second molecule, in this example trifluoroacetic acid, a non-coupled spin system, is selectively imaged. At longer echo times, e.g., TE = 1 J there is substantial recovery of the J-modulated signal, which may be solely observed due to T2 decay of the trifluoroacetic acid signal. The method is demonstrated both using phantoms and in vivo.
Original language | English (US) |
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Pages (from-to) | 729-736 |
Number of pages | 8 |
Journal | Magnetic Resonance Imaging |
Volume | 8 |
Issue number | 6 |
DOIs | |
State | Published - 1990 |
Keywords
- F MRI
- Fluorocarbon
- J-modulation
- Spectral editing
ASJC Scopus subject areas
- Biophysics
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging