A novel editing technique for 19F MRI: Molecule-specific imaging

Ralph P. Mason, Navin Bansal, Evelyn E. Babcock, Ray L. Nunnally, Peter P. Antich

Research output: Contribution to journalArticle

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Abstract

A novel technique is proposed to facilitate the selective imaging of specific molecules from a mixture. The application of the technique presented here demonstrates the ability to selectively produce 19F MR images of either trifluoroacetic acid or the perfluorocarbon emulsion Oxypherol-ET (perfluorotributylamine), when both molecules are present simultaneously. Selective detection is based on the presence of homonuclear J-modulation in one molecule and differential spin-spin relaxation time (T2). Perfluorotributylamine, an A3B2 system, is subject to homonuclear J-modulation, which produces a null signal from the antiphase components of the triplet (A3) when an echo time (TE) = 1 2J is used in a spin-echo image. At this echo time the second molecule, in this example trifluoroacetic acid, a non-coupled spin system, is selectively imaged. At longer echo times, e.g., TE = 1 J there is substantial recovery of the J-modulated signal, which may be solely observed due to T2 decay of the trifluoroacetic acid signal. The method is demonstrated both using phantoms and in vivo.

Original languageEnglish (US)
Pages (from-to)729-736
Number of pages8
JournalMagnetic Resonance Imaging
Volume8
Issue number6
DOIs
StatePublished - 1990

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Keywords

  • F MRI
  • Fluorocarbon
  • J-modulation
  • Spectral editing

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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