A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

Cheng Yang Wu; Santhosh Satapati; Wenjun Gui; R. Max Wynn; Gaurav Sharma; Mingliang Lou; Xiangbing Qi; Shawn C. Burgess; Craig Malloy; Chalermchai Khemtong; A. Dean Sherry; David T. Chuang; Matthew E. Merritt

doi:10.1074/jbc.RA118.002838

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

Cheng Yang Wu, Santhosh Satapati, Wenjun Gui, R. Max Wynn, Gaurav Sharma, Mingliang Lou, Xiangbing Qi, Shawn C. Burgess, Craig Malloy, Chalermchai Khemtong, A. Dean Sherry, David T. Chuang, Matthew E. Merritt

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Original language	English (US)
Pages (from-to)	9604-9613
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	293
Issue number	25
DOIs	https://doi.org/10.1074/jbc.RA118.002838
State	Published - Jun 22 2018

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Wu, C. Y., Satapati, S., Gui, W., Max Wynn, R., Sharma, G., Lou, M., Qi, X., Burgess, S. C., Malloy, C., Khemtong, C., Dean Sherry, A., Chuang, D. T., & Merritt, M. E. (2018). A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity. Journal of Biological Chemistry, 293(25), 9604-9613. https://doi.org/10.1074/jbc.RA118.002838

Wu, CY, Satapati, S, Gui, W, Max Wynn, R , Sharma, G, Lou, M, Qi, X, Burgess, SC , Malloy, C, Khemtong, C, Dean Sherry, A, Chuang, DT & Merritt, ME 2018, 'A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity', Journal of Biological Chemistry, vol. 293, no. 25, pp. 9604-9613. https://doi.org/10.1074/jbc.RA118.002838

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title = "A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity",

author = "Wu, {Cheng Yang} and Santhosh Satapati and Wenjun Gui and {Max Wynn}, R. and Gaurav Sharma and Mingliang Lou and Xiangbing Qi and Burgess, {Shawn C.} and Craig Malloy and Chalermchai Khemtong and {Dean Sherry}, A. and Chuang, {David T.} and Merritt, {Matthew E.}",

note = "Funding Information: This work was supported by National Institutes of Health Grants DK62306, R37-HL034557, and P41-EB015908 and by Welch Foundation Grants I-1286 and I-1804. This work was also supported by National Institutes of Health Grants R01s DK105346, HD087306, DK112865, P41122698, and U24DK097209 and by NSF DMR 1644779 (to M. M.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.",

year = "2018",

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doi = "10.1074/jbc.RA118.002838",

language = "English (US)",

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AU - Wu, Cheng Yang

AU - Satapati, Santhosh

AU - Gui, Wenjun

AU - Max Wynn, R.

AU - Sharma, Gaurav

AU - Lou, Mingliang

AU - Qi, Xiangbing

AU - Burgess, Shawn C.

AU - Malloy, Craig

AU - Khemtong, Chalermchai

AU - Dean Sherry, A.

AU - Chuang, David T.

AU - Merritt, Matthew E.

N1 - Funding Information: This work was supported by National Institutes of Health Grants DK62306, R37-HL034557, and P41-EB015908 and by Welch Foundation Grants I-1286 and I-1804. This work was also supported by National Institutes of Health Grants R01s DK105346, HD087306, DK112865, P41122698, and U24DK097209 and by NSF DMR 1644779 (to M. M.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

PY - 2018/6/22

Y1 - 2018/6/22

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

ASJC Scopus subject areas

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