A novel leptin receptor isoform in rat

May-Yun Wang, Yan Ting Zhou, Christopher B. Newgard, Roger H Unger

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, and Oh-Re. We have identified a new short isoform in the rat, r-OB-Rf, with 6 C-terminal amino acids and a 3' untranslated region without homology to other Ob-R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob-Ra and Ob-Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob-R gene family.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalFEBS Letters
Volume392
Issue number2
DOIs
StatePublished - Aug 26 1996

Keywords

  • Leptin receptor isoform
  • Ob-R gene

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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