A novel microporous polyurethane vascular graft

In vivo evaluation of the UTA prosthesis implanted as infra-renal aortic substitute in dogs

Yves Marois, Ali Akoum, Martin King, Robert Guidoin, Wolf Von Maltzahn, Rajagopal Kowligi, Robert C. Eberhart, Francisco Javier Teijeira, Jean Verreault

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel microporous polyurethane blood conduit developed at the University of Texas at Arlington was implanted as an infra-renal substitute in dogs. The prosthesis was fabricated by precipitating a solution of the polymer with dry nitrogen onto a rotating mandrel. The grafts were sterilized either by gamma radiation (series I) or ethylene oxide (series II); they were implanted for the following prescheduled periods: 4, 24, 48 hours, and J week (short-term) and 2, 4 weeks, 3 and 6 months (medium-term). The thrombohematological characteristics of each animal were evaluated prior to implantation and confirmed that the index of blood coagulability was normal. In the short-term group, five out of eight grafts were patent and three were partially occluded; four grafts in the medium-term group were patent; one was partially occluded; and three were thrombosed at retrieval. One week after implantation, the prostheses were surrounded by an external capsule, which was present mainly at the two anastomoses. The external capsule covered the entire graft at 3 months. No kinking of the grafts was observed and the presence of a mild yellow stain related to bilirubin uptake was detected at 2 weeks, 1, 3, and 6 months. Histological studies have revealed the formation of a thin internal capsule at both anastomoses, 2 weeks postimplantation, which was not anchored to the graft wall. In the medium-term group, the thrombosed grafts failed to develop an internal capsule, whereas the patent graft exhibited a thick internal capsule made of neocollagenous tissue over the entire graft. This new microporous polyurethane prosthesis did not perform satisfactorily as an infra-renal substitute in dogs and its in vivo stability requires further assessment. Thus, the concept of a polyurethane with closed pores does not achieve what was anticipated.

Original languageEnglish (US)
Pages (from-to)273-288
Number of pages16
JournalJournal of Investigative Surgery
Volume6
Issue number3
DOIs
StatePublished - 1993

Fingerprint

Polyurethanes
Prostheses and Implants
Blood Vessels
Dogs
Transplants
Kidney
Internal Capsule
Thrombosis
Prosthesis Implantation
Ethylene Oxide
Gamma Rays
Bilirubin
Polymers
Coloring Agents
Nitrogen

Keywords

  • Arterial bypass
  • Arterial graft
  • Implantation
  • Keywords Blood conduit
  • Polyurethane grafts

ASJC Scopus subject areas

  • Surgery

Cite this

A novel microporous polyurethane vascular graft : In vivo evaluation of the UTA prosthesis implanted as infra-renal aortic substitute in dogs. / Marois, Yves; Akoum, Ali; King, Martin; Guidoin, Robert; Maltzahn, Wolf Von; Kowligi, Rajagopal; Eberhart, Robert C.; Teijeira, Francisco Javier; Verreault, Jean.

In: Journal of Investigative Surgery, Vol. 6, No. 3, 1993, p. 273-288.

Research output: Contribution to journalArticle

Marois, Y, Akoum, A, King, M, Guidoin, R, Maltzahn, WV, Kowligi, R, Eberhart, RC, Teijeira, FJ & Verreault, J 1993, 'A novel microporous polyurethane vascular graft: In vivo evaluation of the UTA prosthesis implanted as infra-renal aortic substitute in dogs', Journal of Investigative Surgery, vol. 6, no. 3, pp. 273-288. https://doi.org/10.3109/08941939309141617
Marois, Yves ; Akoum, Ali ; King, Martin ; Guidoin, Robert ; Maltzahn, Wolf Von ; Kowligi, Rajagopal ; Eberhart, Robert C. ; Teijeira, Francisco Javier ; Verreault, Jean. / A novel microporous polyurethane vascular graft : In vivo evaluation of the UTA prosthesis implanted as infra-renal aortic substitute in dogs. In: Journal of Investigative Surgery. 1993 ; Vol. 6, No. 3. pp. 273-288.
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