A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura, Yoko Tomobe, Mieko Kobayashi, Youji Mitsui, Yoshio Yazaki, Katsutoshi Goto, Tomoh Masaki

Research output: Contribution to journalArticle

9655 Citations (Scopus)

Abstract

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalNature
Volume332
Issue number6163
StatePublished - 1988

Fingerprint

Endothelins
Vasoconstrictor Agents
Endothelial Cells
Peptides
Neurotoxins
Endothelin-1
Cardiovascular System
Ion Channels
Endothelium
Organism Cloning
Complementary DNA
Gene Expression

ASJC Scopus subject areas

  • General

Cite this

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., ... Masaki, T. (1988). A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 332(6163), 411-415.

A novel potent vasoconstrictor peptide produced by vascular endothelial cells. / Yanagisawa, Masashi; Kurihara, Hiroki; Kimura, Sadao; Tomobe, Yoko; Kobayashi, Mieko; Mitsui, Youji; Yazaki, Yoshio; Goto, Katsutoshi; Masaki, Tomoh.

In: Nature, Vol. 332, No. 6163, 1988, p. 411-415.

Research output: Contribution to journalArticle

Yanagisawa, M, Kurihara, H, Kimura, S, Tomobe, Y, Kobayashi, M, Mitsui, Y, Yazaki, Y, Goto, K & Masaki, T 1988, 'A novel potent vasoconstrictor peptide produced by vascular endothelial cells', Nature, vol. 332, no. 6163, pp. 411-415.
Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332(6163):411-415.
Yanagisawa, Masashi ; Kurihara, Hiroki ; Kimura, Sadao ; Tomobe, Yoko ; Kobayashi, Mieko ; Mitsui, Youji ; Yazaki, Yoshio ; Goto, Katsutoshi ; Masaki, Tomoh. / A novel potent vasoconstrictor peptide produced by vascular endothelial cells. In: Nature. 1988 ; Vol. 332, No. 6163. pp. 411-415.
@article{799fb11ad81d41d0a2eaaac9691fda16,
title = "A novel potent vasoconstrictor peptide produced by vascular endothelial cells",
abstract = "An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.",
author = "Masashi Yanagisawa and Hiroki Kurihara and Sadao Kimura and Yoko Tomobe and Mieko Kobayashi and Youji Mitsui and Yoshio Yazaki and Katsutoshi Goto and Tomoh Masaki",
year = "1988",
language = "English (US)",
volume = "332",
pages = "411--415",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6163",

}

TY - JOUR

T1 - A novel potent vasoconstrictor peptide produced by vascular endothelial cells

AU - Yanagisawa, Masashi

AU - Kurihara, Hiroki

AU - Kimura, Sadao

AU - Tomobe, Yoko

AU - Kobayashi, Mieko

AU - Mitsui, Youji

AU - Yazaki, Yoshio

AU - Goto, Katsutoshi

AU - Masaki, Tomoh

PY - 1988

Y1 - 1988

N2 - An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

AB - An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

UR - http://www.scopus.com/inward/record.url?scp=0023859136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023859136&partnerID=8YFLogxK

M3 - Article

VL - 332

SP - 411

EP - 415

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6163

ER -