A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant: A case report

Leah Cohen, Jeannette Guarner, William R. Hunt

Research output: Contribution to journalArticle

Abstract

Background: Lung transplantation remains an important potential therapeutic option for end-stage lung disease. It can improve quality of life and in some cases be a life-lengthening therapy. Despite the possible benefits, there are also many potential complications following transplantation. Here we describe a novel presentation of nontuberculous mycobacterium manifesting as an endobronchial mass developing 4 years after lung transplantation. Case presentation: A 66-year-old African-American woman presented with progressive dyspnea, cough, and persistent wheezing of 2 months' duration. She had a distant history of breast cancer and received bilateral lung transplantation due to end-stage pulmonary fibrosis 4 years prior to her current presentation. She denied fevers, but did endorse night sweats. She had diffuse expiratory wheezing on auscultation. Chest computed tomography imaging showed an endobronchial soft tissue lesion nearly occluding the left mainstem bronchus, which was concerning for endobronchial carcinoma. Rigid bronchoscopy demonstrated a fibrinous mass protruding into the left mainstem proximal to the anastomosis. A pathology report noted fragments of partially necrotic granulation tissue in addition to scant fragments of focally ulcerated bronchial mucosa. Both the tissue culture and bronchial wash stained positively for acid-fast bacilli and grew Mycobacterium avium complex. Conclusions: Nontuberculous mycobacterium pulmonary disease is common post lung transplant and risk factors are related to immunosuppression and history of structural lung disease. Mycobacterium avium complex presenting as an endobronchial lesion in a patient post lung transplant is a novel presentation.

Original languageEnglish (US)
Article number240
JournalJournal of Medical Case Reports
Volume11
Issue number1
DOIs
StatePublished - Aug 28 2017

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Mycobacterium avium Complex
Lung Transplantation
Lung Diseases
Nontuberculous Mycobacteria
Respiratory Sounds
Transplants
Lung
Auscultation
Granulation Tissue
Sweat
Pulmonary Fibrosis
Bronchoscopy
Bronchi
Cough
African Americans
Dyspnea
Immunosuppression
Bacillus
Mucous Membrane
Fever

Keywords

  • Case report
  • Endobronchial mass
  • Immunosuppression
  • Lung transplant
  • Mycobacterium avium complex
  • Nontuberculous mycobacterium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant : A case report. / Cohen, Leah; Guarner, Jeannette; Hunt, William R.

In: Journal of Medical Case Reports, Vol. 11, No. 1, 240, 28.08.2017.

Research output: Contribution to journalArticle

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