A novel serum protein similar to C1q, produced exclusively in adipocytes

P. E. Scherer, S. Williams, M. Fogliano, G. Baldini, H. F. Lodish

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Abstract

We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation- specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum protein. Acrp30 may be a factor that participates in the delicately balanced system of energy homeostasis involving food intake and carbohydrate and lipid catabolism. Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes.

Original languageEnglish (US)
Pages (from-to)26746-26749
Number of pages4
JournalJournal of Biological Chemistry
Volume270
Issue number45
DOIs
Publication statusPublished - 1995

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ASJC Scopus subject areas

  • Biochemistry

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