A one and a two ... expanding roles for poly(ADP-ribose) polymerases in metabolism

Xin Luo, W. Lee Kraus

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

In two related papers in this issue, Bai et al. (2011a, 2011b) observe that PARP-1- or PARP-2-deficient mice show increased energy expenditure and protection against diet-induced obesity. This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD + levels or by promoting SIRT1 expression.

Original languageEnglish (US)
Pages (from-to)353-355
Number of pages3
JournalCell Metabolism
Volume13
Issue number4
DOIs
StatePublished - Apr 6 2011

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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