Abstract
Pyrido[2,3-b][1,4]oxazin-2-ones are conveniently prepared in excellent yields by a one-pot annulation of N-substituted-2-chloroacetamides with 2-halo-3-hydroxypyridines with use of cesium carbonate in refluxing acetonitrile. The key transformation features a Smiles rearrangement of the initial O-alkylation product and subsequent cyclization.
Original language | English (US) |
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Pages (from-to) | 7918-7920 |
Number of pages | 3 |
Journal | Journal of Organic Chemistry |
Volume | 68 |
Issue number | 20 |
DOIs | |
State | Published - Oct 3 2003 |
ASJC Scopus subject areas
- Organic Chemistry