A paradigm to investigate the self-regulation of cocaine administration in humans

Atapol Sughondhabirom, Diwakar Jain, Ralitza Gueorguieva, Vladimir Coric, Robert Berman, Wendy J. Lynch, David Self, Peter Jatlow, Robert T. Malison

Research output: Contribution to journalArticle

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Abstract

Introduction: Current laboratory paradigms of human cocaine administration generally dictate the timing of drug access in ways that may limit assessing aspects of cocaine-taking behavior. Patient-controlled analgesia (PCA) methods, which allow individuals less restricted access to narcotic (i.e., opiate) analgesics, have proven safe and clinically effective for self-regulated treatment of pain. The current study assessed the feasibility, safety, and validity of a model of ad libitum cocaine self-administration, in which participants self-selected the timing of cocaine infusions, using PCA techniques. Methods: Eight nontreatment seeking, otherwise medically healthy, experienced cocaine users participated in a double-blind, placebo-controlled, escalating-dose regimen of intravenous cocaine (0, 8, 16, and 32 mg per 70 kg) on 4 test days, during which time participants had 2 h of access to cocaine via manual presses of a corded PCA pump button under a fixed ratio 1: time-out 5-min schedule. Results: Procedures were well-tolerated by participants, and no significant adverse events were noted. Measures of cocaine self-administration (e.g., number of responses and interinfusion intervals) indicated a significant main effect of cocaine dose, consistent with predicted dose-response relationships (i.e., decreasing responses and increasing interinfusion intervals with increasing injection dose). Participants appeared to regulate their cocaine intake in a carefully controlled manner, using considerably less cocaine (about half) that permitted by pump loading, PCA parameters, and session duration. Conclusions: Data from this study support the validity of our PCA paradigm. Moreover, results suggest the apparent feasibility and safety of allowing experienced users to self-select the timing of cocaine infusions to intervals as short as 5 min. Such procedures may enhance our ability to identify effective pharmacological treatments for cocaine addiction.

Original languageEnglish (US)
Pages (from-to)436-446
Number of pages11
JournalPsychopharmacology
Volume180
Issue number3
DOIs
StatePublished - Jul 2005

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Cocaine
Patient-Controlled Analgesia
Self Administration
Self-Control
Opiate Alkaloids
Safety
Cocaine-Related Disorders
Aptitude
Narcotics
Feasibility Studies
Analgesics
Appointments and Schedules
Placebos
Pharmacology
Pain
Injections

ASJC Scopus subject areas

  • Pharmacology

Cite this

Sughondhabirom, A., Jain, D., Gueorguieva, R., Coric, V., Berman, R., Lynch, W. J., ... Malison, R. T. (2005). A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology, 180(3), 436-446. https://doi.org/10.1007/s00213-005-2192-8

A paradigm to investigate the self-regulation of cocaine administration in humans. / Sughondhabirom, Atapol; Jain, Diwakar; Gueorguieva, Ralitza; Coric, Vladimir; Berman, Robert; Lynch, Wendy J.; Self, David; Jatlow, Peter; Malison, Robert T.

In: Psychopharmacology, Vol. 180, No. 3, 07.2005, p. 436-446.

Research output: Contribution to journalArticle

Sughondhabirom, A, Jain, D, Gueorguieva, R, Coric, V, Berman, R, Lynch, WJ, Self, D, Jatlow, P & Malison, RT 2005, 'A paradigm to investigate the self-regulation of cocaine administration in humans', Psychopharmacology, vol. 180, no. 3, pp. 436-446. https://doi.org/10.1007/s00213-005-2192-8
Sughondhabirom A, Jain D, Gueorguieva R, Coric V, Berman R, Lynch WJ et al. A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology. 2005 Jul;180(3):436-446. https://doi.org/10.1007/s00213-005-2192-8
Sughondhabirom, Atapol ; Jain, Diwakar ; Gueorguieva, Ralitza ; Coric, Vladimir ; Berman, Robert ; Lynch, Wendy J. ; Self, David ; Jatlow, Peter ; Malison, Robert T. / A paradigm to investigate the self-regulation of cocaine administration in humans. In: Psychopharmacology. 2005 ; Vol. 180, No. 3. pp. 436-446.
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AU - Coric, Vladimir

AU - Berman, Robert

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