A Paramagnetic CEST Agent for Imaging Glucose by MRI

Shanrong Zhang, Robert Trokowski, A. Dean Sherry

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The europium(III) complex of a DOTA?tetraamide ligand (DOTA = 1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acids) containing two phenyl boronate pendent arms binds glucose reversibly with an association constant of 383 M-1 at pH 7. Glucose binding results in slowing of water exchange between a single Eu(III)-bound water molecule and bulk water, and this can be imaged by MRI using chemical exchange saturation transfer (CEST) imaging sequence. This metabolite-responsive paramagnetic CEST agent responds to changes in glucose over the physiologically important range (0?20 mM), and thus it offers the possibility of high-sensitivity MR imaging glucose in tissues using bulk water protons as antenna.

Original languageEnglish (US)
Pages (from-to)15288-15289
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number50
DOIs
StatePublished - Dec 17 2003

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Magnetic resonance imaging
Glucose
Imaging techniques
Water
Europium
Metabolites
Protons
Ligands
Association reactions
Tissue
Antennas
Molecules
Acids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A Paramagnetic CEST Agent for Imaging Glucose by MRI. / Zhang, Shanrong; Trokowski, Robert; Sherry, A. Dean.

In: Journal of the American Chemical Society, Vol. 125, No. 50, 17.12.2003, p. 15288-15289.

Research output: Contribution to journalArticle

Zhang, Shanrong ; Trokowski, Robert ; Sherry, A. Dean. / A Paramagnetic CEST Agent for Imaging Glucose by MRI. In: Journal of the American Chemical Society. 2003 ; Vol. 125, No. 50. pp. 15288-15289.
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