A Paramagnetic CEST Agent for Imaging Glucose by MRI

Shanrong Zhang, Robert Trokowski, A. Dean Sherry

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

The europium(III) complex of a DOTA?tetraamide ligand (DOTA = 1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acids) containing two phenyl boronate pendent arms binds glucose reversibly with an association constant of 383 M-1 at pH 7. Glucose binding results in slowing of water exchange between a single Eu(III)-bound water molecule and bulk water, and this can be imaged by MRI using chemical exchange saturation transfer (CEST) imaging sequence. This metabolite-responsive paramagnetic CEST agent responds to changes in glucose over the physiologically important range (0?20 mM), and thus it offers the possibility of high-sensitivity MR imaging glucose in tissues using bulk water protons as antenna.

Original languageEnglish (US)
Pages (from-to)15288-15289
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number50
DOIs
StatePublished - Dec 17 2003

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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