A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity

D. Gomika Udugamasooriya, Sean P. Dineen, Rolf A. Brekken, Thomas Kodadek

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

We report a two-color, cell-based screen to identify specific receptor-binding compounds in a combinatorial library of peptoids displayed on beads. We apply this strategy to the isolation of vascular endothelial growth factor receptor 2 (VEGFR2)-binding peptoids. A dimeric derivative of one of these lead compounds is shown to be an antagonist of VEGFR2 activity both in vitro and in vivo. This methodology provides a potentially general route to synthetic molecules that bind integral membrane receptors with affinities and specificities similar to those of antibodies, but which are far smaller and easier to make and manipulate.

Original languageEnglish (US)
Pages (from-to)5744-5752
Number of pages9
JournalJournal of the American Chemical Society
Volume130
Issue number17
DOIs
StatePublished - Apr 30 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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