A permutation test for the robust sib-pair linkage method

Y. Wan, J. Cohen, R. Guerra

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The robust sib-pair method introduced by Haseman and Elston (1972) is one of the most widely circulated allele-sharing methods for linkage analysis. The procedure evaluates linkage by significance testing of a regression coefficient and, hence, a standard t-test has traditionally been applied despite known violations of the statistical assumptions underlying the test. We present a permutation based reference distribution for the estimate of the regression coefficient that is motivated by genetic principles rather than by standard regression testing procedures. The permutation test approximates Mendelian co-segregation under the null hypothesis of no linkage, making it a very natural approach. Theory and simulations show that the conventional t-test approximates the permutation test quite well, even when dependent sib pairs are used for analysis. These results thus indirectly address concerns over the t-test. To illustrate the permutation test using real data we applied the procedure to two lipoprotein systems that have been well characterized.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalAnnals of Human Genetics
Volume61
Issue number1
StatePublished - Jan 1997

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Lipoproteins
Alleles

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

A permutation test for the robust sib-pair linkage method. / Wan, Y.; Cohen, J.; Guerra, R.

In: Annals of Human Genetics, Vol. 61, No. 1, 01.1997, p. 79-87.

Research output: Contribution to journalArticle

Wan, Y. ; Cohen, J. ; Guerra, R. / A permutation test for the robust sib-pair linkage method. In: Annals of Human Genetics. 1997 ; Vol. 61, No. 1. pp. 79-87.
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