TY - JOUR
T1 - A permutation test for the robust sib-pair linkage method
AU - Wan, Y.
AU - Cohen, J.
AU - Guerra, R.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1997/1
Y1 - 1997/1
N2 - The robust sib-pair method introduced by Haseman and Elston (1972) is one of the most widely circulated allele-sharing methods for linkage analysis. The procedure evaluates linkage by significance testing of a regression coefficient and, hence, a standard t-test has traditionally been applied despite known violations of the statistical assumptions underlying the test. We present a permutation based reference distribution for the estimate of the regression coefficient that is motivated by genetic principles rather than by standard regression testing procedures. The permutation test approximates Mendelian co-segregation under the null hypothesis of no linkage, making it a very natural approach. Theory and simulations show that the conventional t-test approximates the permutation test quite well, even when dependent sib pairs are used for analysis. These results thus indirectly address concerns over the t-test. To illustrate the permutation test using real data we applied the procedure to two lipoprotein systems that have been well characterized.
AB - The robust sib-pair method introduced by Haseman and Elston (1972) is one of the most widely circulated allele-sharing methods for linkage analysis. The procedure evaluates linkage by significance testing of a regression coefficient and, hence, a standard t-test has traditionally been applied despite known violations of the statistical assumptions underlying the test. We present a permutation based reference distribution for the estimate of the regression coefficient that is motivated by genetic principles rather than by standard regression testing procedures. The permutation test approximates Mendelian co-segregation under the null hypothesis of no linkage, making it a very natural approach. Theory and simulations show that the conventional t-test approximates the permutation test quite well, even when dependent sib pairs are used for analysis. These results thus indirectly address concerns over the t-test. To illustrate the permutation test using real data we applied the procedure to two lipoprotein systems that have been well characterized.
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U2 - 10.1017/s0003480096005957
DO - 10.1017/s0003480096005957
M3 - Article
C2 - 9066930
AN - SCOPUS:0031054384
SN - 0003-4800
VL - 61
SP - 77
EP - 85
JO - Annals of Human Genetics
JF - Annals of Human Genetics
IS - 1
ER -