A physiologic-based approach to the evaluation of a patient with hyperkalemia

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Hyperkalemia generally is attributable to cell shifts or abnormal renal potassium excretion. Cell shifts account for transient increases in serum potassium levels, whereas sustained hyperkalemia generally is caused by decreased renal potassium excretion. Impaired renal potassium excretion can be caused by a primary decrease in distal sodium delivery, a primary decrease in mineralocorticoid level or activity, or abnormal cortical collecting duct function. Excessive potassium intake is an infrequent cause of hyperkalemia by itself, but can worsen the severity of hyperkalemia when renal excretion is impaired. Before concluding that a cell shift or renal defect in potassium excretion is present, pseudohyperkalemia should be excluded.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume56
Issue number2
DOIs
StatePublished - 2010

Fingerprint

Hyperkalemia
Potassium
Mineralocorticoids
Sodium
Kidney
Renal Elimination
Serum

Keywords

  • abnormal collecting duct
  • cell shift
  • Hyperkalemia
  • impaired renal potassium excretion
  • pseudohyperkalemia

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

A physiologic-based approach to the evaluation of a patient with hyperkalemia. / Palmer, Biff F.

In: American Journal of Kidney Diseases, Vol. 56, No. 2, 2010, p. 387-393.

Research output: Contribution to journalArticle

@article{ed0ec04b3d3144b99db8f3c3ecccb84f,
title = "A physiologic-based approach to the evaluation of a patient with hyperkalemia",
abstract = "Hyperkalemia generally is attributable to cell shifts or abnormal renal potassium excretion. Cell shifts account for transient increases in serum potassium levels, whereas sustained hyperkalemia generally is caused by decreased renal potassium excretion. Impaired renal potassium excretion can be caused by a primary decrease in distal sodium delivery, a primary decrease in mineralocorticoid level or activity, or abnormal cortical collecting duct function. Excessive potassium intake is an infrequent cause of hyperkalemia by itself, but can worsen the severity of hyperkalemia when renal excretion is impaired. Before concluding that a cell shift or renal defect in potassium excretion is present, pseudohyperkalemia should be excluded.",
keywords = "abnormal collecting duct, cell shift, Hyperkalemia, impaired renal potassium excretion, pseudohyperkalemia",
author = "Palmer, {Biff F.}",
year = "2010",
doi = "10.1053/j.ajkd.2010.01.020",
language = "English (US)",
volume = "56",
pages = "387--393",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - A physiologic-based approach to the evaluation of a patient with hyperkalemia

AU - Palmer, Biff F.

PY - 2010

Y1 - 2010

N2 - Hyperkalemia generally is attributable to cell shifts or abnormal renal potassium excretion. Cell shifts account for transient increases in serum potassium levels, whereas sustained hyperkalemia generally is caused by decreased renal potassium excretion. Impaired renal potassium excretion can be caused by a primary decrease in distal sodium delivery, a primary decrease in mineralocorticoid level or activity, or abnormal cortical collecting duct function. Excessive potassium intake is an infrequent cause of hyperkalemia by itself, but can worsen the severity of hyperkalemia when renal excretion is impaired. Before concluding that a cell shift or renal defect in potassium excretion is present, pseudohyperkalemia should be excluded.

AB - Hyperkalemia generally is attributable to cell shifts or abnormal renal potassium excretion. Cell shifts account for transient increases in serum potassium levels, whereas sustained hyperkalemia generally is caused by decreased renal potassium excretion. Impaired renal potassium excretion can be caused by a primary decrease in distal sodium delivery, a primary decrease in mineralocorticoid level or activity, or abnormal cortical collecting duct function. Excessive potassium intake is an infrequent cause of hyperkalemia by itself, but can worsen the severity of hyperkalemia when renal excretion is impaired. Before concluding that a cell shift or renal defect in potassium excretion is present, pseudohyperkalemia should be excluded.

KW - abnormal collecting duct

KW - cell shift

KW - Hyperkalemia

KW - impaired renal potassium excretion

KW - pseudohyperkalemia

UR - http://www.scopus.com/inward/record.url?scp=77955871521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955871521&partnerID=8YFLogxK

U2 - 10.1053/j.ajkd.2010.01.020

DO - 10.1053/j.ajkd.2010.01.020

M3 - Article

C2 - 20493606

AN - SCOPUS:77955871521

VL - 56

SP - 387

EP - 393

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 2

ER -