Abstract
Background: Past studies suggest that brexpiprazole is an effective adjunctive treatment for major depressive disorder and schizophrenia; however, no studies have examined brexpiprazole for bipolar depression. In this study, we examined the effects of brexpiprazole on mood, cognition, and quality of life in outpatients with bipolar depression. Methods: Twenty-one adults with bipolar disorder (most recent episode depressed) and scoring at least a 25 on the Montgomery-Åsberg Depression Rating Scale (MADRS) were recruited. Brexpiprazole was titrated up to 4 mg/day over the 8-week period. Depressive symptoms were measured using MADRS and Inventory of Depressive Symptomatology Self-report (IDS-SR 30 ). Manic symptoms were measured using Young Mania Rating Scale, quality of life with the Quality of Life in Bipolar Disorder (QOLBD), and cognition with Rey Auditory Verbal Learning Test, Stroop Color Word Test, and Trail Making Test. Results: MADRS and IDS-SR 30 scores decreased from baseline at weeks 4 and 8. YMRS and cognitive scores did not change significantly. QOLBD scores increased from baseline to week 8. Limitations: A limitation to this study is the open-label design. Conclusion: To our knowledge, this is the first study to examine the effects of brexpiprazole on bipolar depression. We found a significant reduction in depressive symptoms and an increase in quality of life.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 315-318 |
| Number of pages | 4 |
| Journal | Journal of Affective Disorders |
| Volume | 249 |
| DOIs | |
| State | Published - Apr 15 2019 |
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Keywords
- Bipolar disorder
- Brexpiprazole
- Cognition
- Depression
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health
Cite this
A pilot study of brexpiprazole for bipolar depression. / Brown, Edson S; Khaleghi, Neusha; Van Enkevort, Erin A; Ivleva, Elena; Nakamura, Alyson K; Holmes, Traci; Mason, Brittany L; Escalante, Chastity.
In: Journal of Affective Disorders, Vol. 249, 15.04.2019, p. 315-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A pilot study of brexpiprazole for bipolar depression
AU - Brown, Edson S
AU - Khaleghi, Neusha
AU - Van Enkevort, Erin A
AU - Ivleva, Elena
AU - Nakamura, Alyson K
AU - Holmes, Traci
AU - Mason, Brittany L
AU - Escalante, Chastity
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Background: Past studies suggest that brexpiprazole is an effective adjunctive treatment for major depressive disorder and schizophrenia; however, no studies have examined brexpiprazole for bipolar depression. In this study, we examined the effects of brexpiprazole on mood, cognition, and quality of life in outpatients with bipolar depression. Methods: Twenty-one adults with bipolar disorder (most recent episode depressed) and scoring at least a 25 on the Montgomery-Åsberg Depression Rating Scale (MADRS) were recruited. Brexpiprazole was titrated up to 4 mg/day over the 8-week period. Depressive symptoms were measured using MADRS and Inventory of Depressive Symptomatology Self-report (IDS-SR 30 ). Manic symptoms were measured using Young Mania Rating Scale, quality of life with the Quality of Life in Bipolar Disorder (QOLBD), and cognition with Rey Auditory Verbal Learning Test, Stroop Color Word Test, and Trail Making Test. Results: MADRS and IDS-SR 30 scores decreased from baseline at weeks 4 and 8. YMRS and cognitive scores did not change significantly. QOLBD scores increased from baseline to week 8. Limitations: A limitation to this study is the open-label design. Conclusion: To our knowledge, this is the first study to examine the effects of brexpiprazole on bipolar depression. We found a significant reduction in depressive symptoms and an increase in quality of life.
AB - Background: Past studies suggest that brexpiprazole is an effective adjunctive treatment for major depressive disorder and schizophrenia; however, no studies have examined brexpiprazole for bipolar depression. In this study, we examined the effects of brexpiprazole on mood, cognition, and quality of life in outpatients with bipolar depression. Methods: Twenty-one adults with bipolar disorder (most recent episode depressed) and scoring at least a 25 on the Montgomery-Åsberg Depression Rating Scale (MADRS) were recruited. Brexpiprazole was titrated up to 4 mg/day over the 8-week period. Depressive symptoms were measured using MADRS and Inventory of Depressive Symptomatology Self-report (IDS-SR 30 ). Manic symptoms were measured using Young Mania Rating Scale, quality of life with the Quality of Life in Bipolar Disorder (QOLBD), and cognition with Rey Auditory Verbal Learning Test, Stroop Color Word Test, and Trail Making Test. Results: MADRS and IDS-SR 30 scores decreased from baseline at weeks 4 and 8. YMRS and cognitive scores did not change significantly. QOLBD scores increased from baseline to week 8. Limitations: A limitation to this study is the open-label design. Conclusion: To our knowledge, this is the first study to examine the effects of brexpiprazole on bipolar depression. We found a significant reduction in depressive symptoms and an increase in quality of life.
KW - Bipolar disorder
KW - Brexpiprazole
KW - Cognition
KW - Depression
UR - http://www.scopus.com/inward/record.url?scp=85061819996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061819996&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2019.02.056
DO - 10.1016/j.jad.2019.02.056
M3 - Article
C2 - 30802696
AN - SCOPUS:85061819996
VL - 249
SP - 315
EP - 318
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -