A population-based study of Parkinsonism in an Amish community

Brad A. Racette, Laura M. Good, Abigail M. Kissel, Susan R. Criswell, Joel S. Perlmutter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Parkinson's disease (PD) is a neurodegenerative disorder with unknown cause. Genetic mutations account for a minority of cases but the role of environmental factors is unclear. Methods: We performed a population-based screening for PD in subjects in an Amish community over age 60. PD was diagnosed using standard clinical criteria and the Unified Parkinson Disease Rating Scale motor subsection 3 (UPDRS3). Community prevalence was calculated. We constructed a community pedigree and calculated kinship coefficients, a measure of relatedness between 2 subjects, for every pair of subjects in diagnostic categories: clinically definite PD, UPDRS3 score >9, Mini-Mental State Exam (MMSE) score <25, and normal. Results: Of 262 eligible subjects, 213 agreed to participate, 15 had PD, 43 had MMSE <25, 73 had UPDRS3 >9. The prevalence of PD was 5,703/100,000 with increasing prevalence in every decade of age. Excluding first-degree relatives, normal subjects were more related to each other (0.0102, SD = 0.0266) than subjects with clinically definite PD (0.0054, SD = 0.0100; p = 0.00003), subjects with UPDRS >9 (0.0076, SD = 0.0155; p = 0.00001), and subjects with MMSE <25 (0.0090, SD = 0.0180; p = 0.00003). Conclusions: PD and parkinsonian signs are common in this population and the prevalence increases with age. The finding that subjects with PD were not more related than normal subjects suggests that environmental factors may contribute to the parkinsonian phenotype in this community.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalNeuroepidemiology
Volume33
Issue number3
DOIs
StatePublished - Oct 2009

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Amish
Parkinsonian Disorders
Parkinson Disease
Population
Pedigree
Neurodegenerative Diseases

Keywords

  • Environment
  • Parkinson's disease
  • Parkinsonism

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Racette, B. A., Good, L. M., Kissel, A. M., Criswell, S. R., & Perlmutter, J. S. (2009). A population-based study of Parkinsonism in an Amish community. Neuroepidemiology, 33(3), 225-230. https://doi.org/10.1159/000229776

A population-based study of Parkinsonism in an Amish community. / Racette, Brad A.; Good, Laura M.; Kissel, Abigail M.; Criswell, Susan R.; Perlmutter, Joel S.

In: Neuroepidemiology, Vol. 33, No. 3, 10.2009, p. 225-230.

Research output: Contribution to journalArticle

Racette, BA, Good, LM, Kissel, AM, Criswell, SR & Perlmutter, JS 2009, 'A population-based study of Parkinsonism in an Amish community', Neuroepidemiology, vol. 33, no. 3, pp. 225-230. https://doi.org/10.1159/000229776
Racette BA, Good LM, Kissel AM, Criswell SR, Perlmutter JS. A population-based study of Parkinsonism in an Amish community. Neuroepidemiology. 2009 Oct;33(3):225-230. https://doi.org/10.1159/000229776
Racette, Brad A. ; Good, Laura M. ; Kissel, Abigail M. ; Criswell, Susan R. ; Perlmutter, Joel S. / A population-based study of Parkinsonism in an Amish community. In: Neuroepidemiology. 2009 ; Vol. 33, No. 3. pp. 225-230.
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