A Possible Mechanism for Hypertension Induced by Oral Contraceptives: Diminished Feedback Suppression of Renin Release

T. Saruta, G. A. Saade, Norman M Kaplan

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

Hypertension appeared in 10 of 56 previously normotensive women and was aggravated in one of six previously hypertensive women during administration of an estrogen-containing oral contraceptive. Reninangiotensin system studies revealed an increase in plasma renin activity which could be attributed in part to an estrogen-induced increase in the substrate upon which the enzyme acts. But the plasma renin concentration, a closer approximation of the actual amount of enzyme, was significantly greater in those whose blood pressure rose while they were taking oral contraceptives. According to present understanding of the renin-angiotensin system, an increase in substrate should lead to an increase in the amount of angiotensin generated and, in turn, to a feedback suppression of renin release. Hypertension induced by oral contraceptives may be related to a diminished suppression of renin release.

Original languageEnglish (US)
Pages (from-to)621-626
Number of pages6
JournalArchives of Internal Medicine
Volume126
Issue number4
DOIs
StatePublished - Oct 1970

ASJC Scopus subject areas

  • Internal Medicine

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