A potent transactivation domain mimic with activity in living cells

Bo Liu, Prasanna G. Alluri, Peng Yu, Thomas Kodadek

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Transcriptional coactivator-binding peptoids were isolated from a large combinatorial library. One of these molecules is shown to function as a potent activation domain surrogate in mammalian cells. Up to a 900-fold increase in expression of a Gal4-responsive reporter gene is observed when a steroid conjugate of the peptoid is incubated with HeLa cells expressing a Gal4 DNA-binding domain (DBD)-glucocorticoid receptor ligand-binding domain (GRLBD) fusion protein.

Original languageEnglish (US)
Pages (from-to)8254-8255
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number23
DOIs
StatePublished - Jun 15 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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