A potent transactivation domain mimic with activity in living cells

Bo Liu; Prasanna G. Alluri; Peng Yu; Thomas Kodadek

doi:10.1021/ja0515295

A potent transactivation domain mimic with activity in living cells

Bo Liu, Prasanna G. Alluri, Peng Yu, Thomas Kodadek

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Transcriptional coactivator-binding peptoids were isolated from a large combinatorial library. One of these molecules is shown to function as a potent activation domain surrogate in mammalian cells. Up to a 900-fold increase in expression of a Gal4-responsive reporter gene is observed when a steroid conjugate of the peptoid is incubated with HeLa cells expressing a Gal4 DNA-binding domain (DBD)-glucocorticoid receptor ligand-binding domain (GRLBD) fusion protein.

Original language	English (US)
Pages (from-to)	8254-8255
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	23
DOIs	https://doi.org/10.1021/ja0515295
State	Published - Jun 15 2005

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0515295

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AU - Kodadek, Thomas

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A potent transactivation domain mimic with activity in living cells

Abstract

ASJC Scopus subject areas

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