A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs)

V. Raj Gopal, S. G. Jagadeesh, Y. Krishna Reddy, A. Bandyopadhyay, Jorge H. Capdevila, J. R. Falck

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Suzuki-Miyaura cross-coupling of cis-vinylbromide 6, obtained in three steps from diol 4, with functionalized boranes provides a practical, stereospecific route to the title CYP P450 eicosanoids.

Original languageEnglish (US)
Pages (from-to)2563-2565
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number12
DOIs
StatePublished - Mar 15 2004

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Boranes
Eicosanoids
Acids
20-hydroxy-5,8,11,14-eicosatetraenoic acid
19-hydroxy-5,8,11,14-eicosatetraenoic acid

Keywords

  • Biologically active compounds
  • Eicosanoids
  • Lipids
  • Suzuki reactions

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs). / Gopal, V. Raj; Jagadeesh, S. G.; Reddy, Y. Krishna; Bandyopadhyay, A.; Capdevila, Jorge H.; Falck, J. R.

In: Tetrahedron Letters, Vol. 45, No. 12, 15.03.2004, p. 2563-2565.

Research output: Contribution to journalArticle

Gopal, V. Raj ; Jagadeesh, S. G. ; Reddy, Y. Krishna ; Bandyopadhyay, A. ; Capdevila, Jorge H. ; Falck, J. R. / A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs). In: Tetrahedron Letters. 2004 ; Vol. 45, No. 12. pp. 2563-2565.
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AU - Reddy, Y. Krishna

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AU - Capdevila, Jorge H.

AU - Falck, J. R.

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