A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs)

V. Raj Gopal, S. G. Jagadeesh, Y. Krishna Reddy, A. Bandyopadhyay, Jorge H. Capdevila, J. R. Falck

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Suzuki-Miyaura cross-coupling of cis-vinylbromide 6, obtained in three steps from diol 4, with functionalized boranes provides a practical, stereospecific route to the title CYP P450 eicosanoids.

Original languageEnglish (US)
Pages (from-to)2563-2565
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number12
DOIs
StatePublished - Mar 15 2004

Keywords

  • Biologically active compounds
  • Eicosanoids
  • Lipids
  • Suzuki reactions

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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