A preliminary comparison of two-dimensional speckle tracking echocardiography and pressure–volume loop analysis in patients with Fontan physiology: The role of ventricular morphology

David Steflik, Ryan J. Butts, George H. Baker, Varsha Bandisode, Andrew Savage, Andrew M. Atz, Shahryar M. Chowdhury

Research output: Contribution to journalArticle

Abstract

Objective: Speckle tracking echocardiography (STE) may be a useful modality for assessing ventricular performance in patients with single ventricle physiology. However, STE's ability to accurately assess ventricular performance in this population is unknown. The objective of this study was to perform a preliminary comparison of STE measures of myocardial deformation to reference standard measures of function derived from pressure–volume loop (PVL) analysis. Design: This was a secondary analysis of a prospective study investigating PVLs in patients with Fontan physiology. PVLs were recorded using microconductance catheters. PVL indices included end-systolic elastance (Ees), arterial elastance (Ea), ventriculo-arterial coupling (Ea/Ees), and the isovolumic relaxation time constant (tau). Patients were included if they had an echocardiogram within 1 month of their catheterization. STE was performed retrospectively using vendor independent software. Results: Seventeen patients had echocardiograms available for analysis, 12 were right ventricular (RV) dominant. The median age was 8 years (IQR 5–17 years). Circumferential strain (r=−.72, P≤.01) and strain rate (r=−.61, P=.04) correlated with Ea/Ees in those with RV-dominant morphology. Longitudinal strain rate correlated with Ees in those with LV-dominant morphology (r=−.98, P≤.01). Longitudinal EDSR correlated with tau in those with LV-dominant morphology (r=−.90, P=.04). Conclusions: In this limited sample, circumferential measures of deformation correlated with PVL measures better in patients with RV morphology, while longitudinal measures correlated better with PVL measures in patients with LV morphology. Further validation and investigation into the clinical usefulness of these measures are warranted.

Original languageEnglish (US)
Pages (from-to)1353-1359
Number of pages7
JournalEchocardiography
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2017

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Keywords

  • Fontan
  • pressure–volume loop
  • speckle tracking echocardiography
  • ventricular function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

A preliminary comparison of two-dimensional speckle tracking echocardiography and pressure–volume loop analysis in patients with Fontan physiology : The role of ventricular morphology. / Steflik, David; Butts, Ryan J.; Baker, George H.; Bandisode, Varsha; Savage, Andrew; Atz, Andrew M.; Chowdhury, Shahryar M.

In: Echocardiography, Vol. 34, No. 9, 01.09.2017, p. 1353-1359.

Research output: Contribution to journalArticle

Steflik, David ; Butts, Ryan J. ; Baker, George H. ; Bandisode, Varsha ; Savage, Andrew ; Atz, Andrew M. ; Chowdhury, Shahryar M. / A preliminary comparison of two-dimensional speckle tracking echocardiography and pressure–volume loop analysis in patients with Fontan physiology : The role of ventricular morphology. In: Echocardiography. 2017 ; Vol. 34, No. 9. pp. 1353-1359.
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abstract = "Objective: Speckle tracking echocardiography (STE) may be a useful modality for assessing ventricular performance in patients with single ventricle physiology. However, STE's ability to accurately assess ventricular performance in this population is unknown. The objective of this study was to perform a preliminary comparison of STE measures of myocardial deformation to reference standard measures of function derived from pressure–volume loop (PVL) analysis. Design: This was a secondary analysis of a prospective study investigating PVLs in patients with Fontan physiology. PVLs were recorded using microconductance catheters. PVL indices included end-systolic elastance (Ees), arterial elastance (Ea), ventriculo-arterial coupling (Ea/Ees), and the isovolumic relaxation time constant (tau). Patients were included if they had an echocardiogram within 1 month of their catheterization. STE was performed retrospectively using vendor independent software. Results: Seventeen patients had echocardiograms available for analysis, 12 were right ventricular (RV) dominant. The median age was 8 years (IQR 5–17 years). Circumferential strain (r=−.72, P≤.01) and strain rate (r=−.61, P=.04) correlated with Ea/Ees in those with RV-dominant morphology. Longitudinal strain rate correlated with Ees in those with LV-dominant morphology (r=−.98, P≤.01). Longitudinal EDSR correlated with tau in those with LV-dominant morphology (r=−.90, P=.04). Conclusions: In this limited sample, circumferential measures of deformation correlated with PVL measures better in patients with RV morphology, while longitudinal measures correlated better with PVL measures in patients with LV morphology. Further validation and investigation into the clinical usefulness of these measures are warranted.",
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AU - Bandisode, Varsha

AU - Savage, Andrew

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N2 - Objective: Speckle tracking echocardiography (STE) may be a useful modality for assessing ventricular performance in patients with single ventricle physiology. However, STE's ability to accurately assess ventricular performance in this population is unknown. The objective of this study was to perform a preliminary comparison of STE measures of myocardial deformation to reference standard measures of function derived from pressure–volume loop (PVL) analysis. Design: This was a secondary analysis of a prospective study investigating PVLs in patients with Fontan physiology. PVLs were recorded using microconductance catheters. PVL indices included end-systolic elastance (Ees), arterial elastance (Ea), ventriculo-arterial coupling (Ea/Ees), and the isovolumic relaxation time constant (tau). Patients were included if they had an echocardiogram within 1 month of their catheterization. STE was performed retrospectively using vendor independent software. Results: Seventeen patients had echocardiograms available for analysis, 12 were right ventricular (RV) dominant. The median age was 8 years (IQR 5–17 years). Circumferential strain (r=−.72, P≤.01) and strain rate (r=−.61, P=.04) correlated with Ea/Ees in those with RV-dominant morphology. Longitudinal strain rate correlated with Ees in those with LV-dominant morphology (r=−.98, P≤.01). Longitudinal EDSR correlated with tau in those with LV-dominant morphology (r=−.90, P=.04). Conclusions: In this limited sample, circumferential measures of deformation correlated with PVL measures better in patients with RV morphology, while longitudinal measures correlated better with PVL measures in patients with LV morphology. Further validation and investigation into the clinical usefulness of these measures are warranted.

AB - Objective: Speckle tracking echocardiography (STE) may be a useful modality for assessing ventricular performance in patients with single ventricle physiology. However, STE's ability to accurately assess ventricular performance in this population is unknown. The objective of this study was to perform a preliminary comparison of STE measures of myocardial deformation to reference standard measures of function derived from pressure–volume loop (PVL) analysis. Design: This was a secondary analysis of a prospective study investigating PVLs in patients with Fontan physiology. PVLs were recorded using microconductance catheters. PVL indices included end-systolic elastance (Ees), arterial elastance (Ea), ventriculo-arterial coupling (Ea/Ees), and the isovolumic relaxation time constant (tau). Patients were included if they had an echocardiogram within 1 month of their catheterization. STE was performed retrospectively using vendor independent software. Results: Seventeen patients had echocardiograms available for analysis, 12 were right ventricular (RV) dominant. The median age was 8 years (IQR 5–17 years). Circumferential strain (r=−.72, P≤.01) and strain rate (r=−.61, P=.04) correlated with Ea/Ees in those with RV-dominant morphology. Longitudinal strain rate correlated with Ees in those with LV-dominant morphology (r=−.98, P≤.01). Longitudinal EDSR correlated with tau in those with LV-dominant morphology (r=−.90, P=.04). Conclusions: In this limited sample, circumferential measures of deformation correlated with PVL measures better in patients with RV morphology, while longitudinal measures correlated better with PVL measures in patients with LV morphology. Further validation and investigation into the clinical usefulness of these measures are warranted.

KW - Fontan

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KW - speckle tracking echocardiography

KW - ventricular function

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