A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders

Kirti Saxena, Leanne Tamm, Annie Walley, Alex Simmons, Nancy Rollins, Jonathan Chia, Jair C. Soares, Graham J. Emslie, Xin Fan, Hao Huang

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective: Although behavioral deficits in bipolar disorder (BPD) are well described, the specific brain white matter (WM) disruptions have not been completely characterized, and neural mechanisms underlying dysfunction in BPD are not well established, particularly for youth with BPD and aggression. This preliminary study utilized diffusion tensor imaging (DTI) to investigate commissural tracts (corpus callosum [CC] and anterior commissure [AC]) in youth with BPD, because disruption of interhemispheric communication may contribute to the emotional deficits that are characteristic of the illness. Method: DTI was used to investigate WM in 10 youth (7-17 years of age) with BPD and 10 typically developing age-matched controls. Tract-based spatial statistics voxel-wise analysis was used to compare fractional anisotropy (FA) of the two groups. We specifically focused on five subdivisions of the midsagittal CC as well as on the decussation of AC, which connects the temporal lobes. Exploratory correlations between FA values and life history of aggression scores were calculated for the BPD group. Results: Youth with BPD had significantly lower FA values in the callosal genu and AC. FA values in the AC were negatively correlated with a life history of aggression in the BPD group. Conclusions: These results contribute to a growing literature implicating a role for the genu of the CC in BPD and are the first to report WM variations in the AC of children with BPD. Taken together with the correlational data for aggression and the role of the AC in emotional processing, our data provide preliminary evidence for a possible association between the structural integrity of the WM of the AC and aggression in pediatric BPD.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalJournal of Child and Adolescent Psychopharmacology
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2012

Fingerprint

Corpus Callosum
Bipolar Disorder
Aggression
Anisotropy
Diffusion Tensor Imaging
Value of Life
Temporal Lobe
Communication
Pediatrics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health

Cite this

A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders. / Saxena, Kirti; Tamm, Leanne; Walley, Annie; Simmons, Alex; Rollins, Nancy; Chia, Jonathan; Soares, Jair C.; Emslie, Graham J.; Fan, Xin; Huang, Hao.

In: Journal of Child and Adolescent Psychopharmacology, Vol. 22, No. 2, 01.04.2012, p. 112-119.

Research output: Contribution to journalArticle

Saxena, Kirti ; Tamm, Leanne ; Walley, Annie ; Simmons, Alex ; Rollins, Nancy ; Chia, Jonathan ; Soares, Jair C. ; Emslie, Graham J. ; Fan, Xin ; Huang, Hao. / A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders. In: Journal of Child and Adolescent Psychopharmacology. 2012 ; Vol. 22, No. 2. pp. 112-119.
@article{c32d81c1fb374df4b8d83f5e8079386e,
title = "A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders",
abstract = "Objective: Although behavioral deficits in bipolar disorder (BPD) are well described, the specific brain white matter (WM) disruptions have not been completely characterized, and neural mechanisms underlying dysfunction in BPD are not well established, particularly for youth with BPD and aggression. This preliminary study utilized diffusion tensor imaging (DTI) to investigate commissural tracts (corpus callosum [CC] and anterior commissure [AC]) in youth with BPD, because disruption of interhemispheric communication may contribute to the emotional deficits that are characteristic of the illness. Method: DTI was used to investigate WM in 10 youth (7-17 years of age) with BPD and 10 typically developing age-matched controls. Tract-based spatial statistics voxel-wise analysis was used to compare fractional anisotropy (FA) of the two groups. We specifically focused on five subdivisions of the midsagittal CC as well as on the decussation of AC, which connects the temporal lobes. Exploratory correlations between FA values and life history of aggression scores were calculated for the BPD group. Results: Youth with BPD had significantly lower FA values in the callosal genu and AC. FA values in the AC were negatively correlated with a life history of aggression in the BPD group. Conclusions: These results contribute to a growing literature implicating a role for the genu of the CC in BPD and are the first to report WM variations in the AC of children with BPD. Taken together with the correlational data for aggression and the role of the AC in emotional processing, our data provide preliminary evidence for a possible association between the structural integrity of the WM of the AC and aggression in pediatric BPD.",
author = "Kirti Saxena and Leanne Tamm and Annie Walley and Alex Simmons and Nancy Rollins and Jonathan Chia and Soares, {Jair C.} and Emslie, {Graham J.} and Xin Fan and Hao Huang",
year = "2012",
month = "4",
day = "1",
doi = "10.1089/cap.2011.0063",
language = "English (US)",
volume = "22",
pages = "112--119",
journal = "Journal of Child and Adolescent Psychopharmacology",
issn = "1044-5463",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

TY - JOUR

T1 - A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders

AU - Saxena, Kirti

AU - Tamm, Leanne

AU - Walley, Annie

AU - Simmons, Alex

AU - Rollins, Nancy

AU - Chia, Jonathan

AU - Soares, Jair C.

AU - Emslie, Graham J.

AU - Fan, Xin

AU - Huang, Hao

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: Although behavioral deficits in bipolar disorder (BPD) are well described, the specific brain white matter (WM) disruptions have not been completely characterized, and neural mechanisms underlying dysfunction in BPD are not well established, particularly for youth with BPD and aggression. This preliminary study utilized diffusion tensor imaging (DTI) to investigate commissural tracts (corpus callosum [CC] and anterior commissure [AC]) in youth with BPD, because disruption of interhemispheric communication may contribute to the emotional deficits that are characteristic of the illness. Method: DTI was used to investigate WM in 10 youth (7-17 years of age) with BPD and 10 typically developing age-matched controls. Tract-based spatial statistics voxel-wise analysis was used to compare fractional anisotropy (FA) of the two groups. We specifically focused on five subdivisions of the midsagittal CC as well as on the decussation of AC, which connects the temporal lobes. Exploratory correlations between FA values and life history of aggression scores were calculated for the BPD group. Results: Youth with BPD had significantly lower FA values in the callosal genu and AC. FA values in the AC were negatively correlated with a life history of aggression in the BPD group. Conclusions: These results contribute to a growing literature implicating a role for the genu of the CC in BPD and are the first to report WM variations in the AC of children with BPD. Taken together with the correlational data for aggression and the role of the AC in emotional processing, our data provide preliminary evidence for a possible association between the structural integrity of the WM of the AC and aggression in pediatric BPD.

AB - Objective: Although behavioral deficits in bipolar disorder (BPD) are well described, the specific brain white matter (WM) disruptions have not been completely characterized, and neural mechanisms underlying dysfunction in BPD are not well established, particularly for youth with BPD and aggression. This preliminary study utilized diffusion tensor imaging (DTI) to investigate commissural tracts (corpus callosum [CC] and anterior commissure [AC]) in youth with BPD, because disruption of interhemispheric communication may contribute to the emotional deficits that are characteristic of the illness. Method: DTI was used to investigate WM in 10 youth (7-17 years of age) with BPD and 10 typically developing age-matched controls. Tract-based spatial statistics voxel-wise analysis was used to compare fractional anisotropy (FA) of the two groups. We specifically focused on five subdivisions of the midsagittal CC as well as on the decussation of AC, which connects the temporal lobes. Exploratory correlations between FA values and life history of aggression scores were calculated for the BPD group. Results: Youth with BPD had significantly lower FA values in the callosal genu and AC. FA values in the AC were negatively correlated with a life history of aggression in the BPD group. Conclusions: These results contribute to a growing literature implicating a role for the genu of the CC in BPD and are the first to report WM variations in the AC of children with BPD. Taken together with the correlational data for aggression and the role of the AC in emotional processing, our data provide preliminary evidence for a possible association between the structural integrity of the WM of the AC and aggression in pediatric BPD.

UR - http://www.scopus.com/inward/record.url?scp=84860000671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860000671&partnerID=8YFLogxK

U2 - 10.1089/cap.2011.0063

DO - 10.1089/cap.2011.0063

M3 - Article

C2 - 22375854

AN - SCOPUS:84860000671

VL - 22

SP - 112

EP - 119

JO - Journal of Child and Adolescent Psychopharmacology

JF - Journal of Child and Adolescent Psychopharmacology

SN - 1044-5463

IS - 2

ER -