A product of mevalonate proximal to isoprenoids is the source of both a necessary growth factor and an inhibitor of cell proliferation.

J. A. Cuthbert, P. E. Lipsky

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

These studies demonstrate that mevalonate or the mevalonate phosphates play a number of regulatory roles in cellular proliferation. They are not only required for cell growth but are also a source of an inhibitor of cell growth. Endogenous concentrations of mevalonate and the mevalonate phosphates are thus critical determinants of cellular proliferation.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalTransactions of the Association of American Physicians
Volume104
StatePublished - 1991

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