A product of mevalonate proximal to isoprenoids is the source of both a necessary growth factor and an inhibitor of cell proliferation.

J. A. Cuthbert, P. E. Lipsky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

These studies demonstrate that mevalonate or the mevalonate phosphates play a number of regulatory roles in cellular proliferation. They are not only required for cell growth but are also a source of an inhibitor of cell growth. Endogenous concentrations of mevalonate and the mevalonate phosphates are thus critical determinants of cellular proliferation.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalTransactions of the Association of American Physicians
Volume104
StatePublished - 1991

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Mevalonic Acid
Growth Inhibitors
Terpenes
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Phosphates
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "These studies demonstrate that mevalonate or the mevalonate phosphates play a number of regulatory roles in cellular proliferation. They are not only required for cell growth but are also a source of an inhibitor of cell growth. Endogenous concentrations of mevalonate and the mevalonate phosphates are thus critical determinants of cellular proliferation.",
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