A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

Ivaylo P. Ivanov; John F. Atkins; Antony J. Michael

doi:10.1093/nar/gkp1037

A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

Ivaylo P. Ivanov, John F. Atkins, Antony J. Michael

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORFmediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.

Original language	English (US)
Article number	gkp1037
Pages (from-to)	353-359
Number of pages	7
Journal	Nucleic acids research
Volume	38
Issue number	2
DOIs	https://doi.org/10.1093/nar/gkp1037
State	Published - Nov 17 2009

ASJC Scopus subject areas

Genetics

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abstract = "In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORFmediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.",

author = "Ivanov, {Ivaylo P.} and Atkins, {John F.} and Michael, {Antony J.}",

note = "Funding Information: National Institute of Health (grant R01 GM079523); Science Foundation Ireland (to J.F.A.); Institute Development Fellowship (BB/E024467/1); from the Biotechnology and Biological Sciences Research Council, UK (to A.J.M.). Funding for open access charge: Science Foundation Ireland.",

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AB - In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORFmediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.

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A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

Abstract

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