A proposed model for endometrial serous carcinogenesis

Wenxin Zheng, Li Xiang, Oluwole Fadare, Beihua Kong

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Endometrial serous carcinomas constitute no more than 10% of endometrial adenocarcinomas, but frequently present at an advanced stage and have a significantly worse prognosis than the more common low-grade and intermediate-grade endometrioid adenocarcinomas. The neoplasm's potential for rapid tumor progression and the high mortality that is associated with advanced-stage disease underscore the importance of understanding endometrial serous carcinogenesis so that its precancers can be diagnosed and an effective therapeutic intervention can be administered. In this study, the authors summarize the current state of knowledge on endometrial serous carcinogenesis and propose a model for its development based on recent work from our group and published data from other researchers. In this model, endometrial serous carcinoma arises predominantly in the resting endometrium, manifesting first as p53 immunoreactive, morphologically normal endometrial cells (p53 signatures), evolving to endometrial glandular dysplasia (which is the first morphologically identifiable precursor lesion), then to serous endometrial intraepithelial carcinoma (a carcinoma with a noninvasive growth pattern in the uterus but which is not infrequently associated with extrauterine disease), and finally into fully developed serous carcinoma. Endometrial glandular dysplasia is a lesion, which can be diagnosed by routine microscopic evaluation, whose ablation or removal may potentially offer the opportunity to prevent the development of the associated malignancy. The diagnostic criteria, practical applicability, and evidentiary basis for the delineation of this lesion are studied.

Original languageEnglish (US)
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Endometrial Neoplasms
Carcinogenesis
Endometrioid Carcinoma
Carcinoma
Neoplasms
Carcinoma in Situ
Endometrium
Uterus
Adenocarcinoma
Research Personnel
Mortality
Growth
Therapeutics

Keywords

  • endometrial cancer
  • endometrial glandular dysplasia
  • endometrial intraepithelial carcinoma
  • endometrial papillary serous carcinoma
  • endometrial serous carcinogenesis

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

A proposed model for endometrial serous carcinogenesis. / Zheng, Wenxin; Xiang, Li; Fadare, Oluwole; Kong, Beihua.

In: American Journal of Surgical Pathology, Vol. 35, No. 1, 01.01.2011.

Research output: Contribution to journalArticle

Zheng, Wenxin ; Xiang, Li ; Fadare, Oluwole ; Kong, Beihua. / A proposed model for endometrial serous carcinogenesis. In: American Journal of Surgical Pathology. 2011 ; Vol. 35, No. 1.
@article{43e11f80a99d4666bd6ee158fb5e491f,
title = "A proposed model for endometrial serous carcinogenesis",
abstract = "Endometrial serous carcinomas constitute no more than 10{\%} of endometrial adenocarcinomas, but frequently present at an advanced stage and have a significantly worse prognosis than the more common low-grade and intermediate-grade endometrioid adenocarcinomas. The neoplasm's potential for rapid tumor progression and the high mortality that is associated with advanced-stage disease underscore the importance of understanding endometrial serous carcinogenesis so that its precancers can be diagnosed and an effective therapeutic intervention can be administered. In this study, the authors summarize the current state of knowledge on endometrial serous carcinogenesis and propose a model for its development based on recent work from our group and published data from other researchers. In this model, endometrial serous carcinoma arises predominantly in the resting endometrium, manifesting first as p53 immunoreactive, morphologically normal endometrial cells (p53 signatures), evolving to endometrial glandular dysplasia (which is the first morphologically identifiable precursor lesion), then to serous endometrial intraepithelial carcinoma (a carcinoma with a noninvasive growth pattern in the uterus but which is not infrequently associated with extrauterine disease), and finally into fully developed serous carcinoma. Endometrial glandular dysplasia is a lesion, which can be diagnosed by routine microscopic evaluation, whose ablation or removal may potentially offer the opportunity to prevent the development of the associated malignancy. The diagnostic criteria, practical applicability, and evidentiary basis for the delineation of this lesion are studied.",
keywords = "endometrial cancer, endometrial glandular dysplasia, endometrial intraepithelial carcinoma, endometrial papillary serous carcinoma, endometrial serous carcinogenesis",
author = "Wenxin Zheng and Li Xiang and Oluwole Fadare and Beihua Kong",
year = "2011",
month = "1",
day = "1",
doi = "10.1097/PAS.0b013e318202772e",
language = "English (US)",
volume = "35",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - A proposed model for endometrial serous carcinogenesis

AU - Zheng, Wenxin

AU - Xiang, Li

AU - Fadare, Oluwole

AU - Kong, Beihua

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Endometrial serous carcinomas constitute no more than 10% of endometrial adenocarcinomas, but frequently present at an advanced stage and have a significantly worse prognosis than the more common low-grade and intermediate-grade endometrioid adenocarcinomas. The neoplasm's potential for rapid tumor progression and the high mortality that is associated with advanced-stage disease underscore the importance of understanding endometrial serous carcinogenesis so that its precancers can be diagnosed and an effective therapeutic intervention can be administered. In this study, the authors summarize the current state of knowledge on endometrial serous carcinogenesis and propose a model for its development based on recent work from our group and published data from other researchers. In this model, endometrial serous carcinoma arises predominantly in the resting endometrium, manifesting first as p53 immunoreactive, morphologically normal endometrial cells (p53 signatures), evolving to endometrial glandular dysplasia (which is the first morphologically identifiable precursor lesion), then to serous endometrial intraepithelial carcinoma (a carcinoma with a noninvasive growth pattern in the uterus but which is not infrequently associated with extrauterine disease), and finally into fully developed serous carcinoma. Endometrial glandular dysplasia is a lesion, which can be diagnosed by routine microscopic evaluation, whose ablation or removal may potentially offer the opportunity to prevent the development of the associated malignancy. The diagnostic criteria, practical applicability, and evidentiary basis for the delineation of this lesion are studied.

AB - Endometrial serous carcinomas constitute no more than 10% of endometrial adenocarcinomas, but frequently present at an advanced stage and have a significantly worse prognosis than the more common low-grade and intermediate-grade endometrioid adenocarcinomas. The neoplasm's potential for rapid tumor progression and the high mortality that is associated with advanced-stage disease underscore the importance of understanding endometrial serous carcinogenesis so that its precancers can be diagnosed and an effective therapeutic intervention can be administered. In this study, the authors summarize the current state of knowledge on endometrial serous carcinogenesis and propose a model for its development based on recent work from our group and published data from other researchers. In this model, endometrial serous carcinoma arises predominantly in the resting endometrium, manifesting first as p53 immunoreactive, morphologically normal endometrial cells (p53 signatures), evolving to endometrial glandular dysplasia (which is the first morphologically identifiable precursor lesion), then to serous endometrial intraepithelial carcinoma (a carcinoma with a noninvasive growth pattern in the uterus but which is not infrequently associated with extrauterine disease), and finally into fully developed serous carcinoma. Endometrial glandular dysplasia is a lesion, which can be diagnosed by routine microscopic evaluation, whose ablation or removal may potentially offer the opportunity to prevent the development of the associated malignancy. The diagnostic criteria, practical applicability, and evidentiary basis for the delineation of this lesion are studied.

KW - endometrial cancer

KW - endometrial glandular dysplasia

KW - endometrial intraepithelial carcinoma

KW - endometrial papillary serous carcinoma

KW - endometrial serous carcinogenesis

UR - http://www.scopus.com/inward/record.url?scp=78650878985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650878985&partnerID=8YFLogxK

U2 - 10.1097/PAS.0b013e318202772e

DO - 10.1097/PAS.0b013e318202772e

M3 - Article

C2 - 21164282

AN - SCOPUS:78650878985

VL - 35

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 1

ER -