A proposed scoring system for assessment of severity of illness in pediatric acute hematogenous osteomyelitis using objective clinical and laboratory findings

Lawson A B Copley, Theresa Barton, Carla Garcia, David Sun, Claudia Gaviria-Agudelo, William T. Gheen, Richard H. Browne

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BACKGROUND: Severity of illness in children with acute hematogenous osteomyelitis (AHO) is variable, ranging from mild, requiring short-duration antibiotic therapy without surgery, to severe, requiring intensive care, multiple surgeries and prolonged hospitalization. This study evaluates severity of illness among children with AHO using clinical and laboratory findings. METHODS: Fifty-six children with AHO, consecutively treated in 2009, were retrospectively studied. Objective clinical, radiographic and laboratory parameters related to severity of illness were gathered for each child. A physician panel was assembled to rank order objective clinical parameters, review clinical data and classify each child as mild, moderate or severe. Statistically significant parameters correlated with length of hospitalization were utilized to devise a severity of illness score and applied to the cohort of children for internal validation. RESULTS: The physician panel had perfect or substantial agreement regarding 7 parameters (ICU admission, intubation, pulmonary involvement, venous thrombosis, multifocal infection, surgeries and febrile days on antibiotics). Parameters that significantly correlated with total length of stay included: C-reactive protein values at admission (P < 0.0001), 48 hours (P < 0.0001) and 96 hours (P < 0.0002); febrile days on antibiotics (P < 0.0001); admission respiratory rate (P = 0.023) and evidence of disseminated disease (P = 0.016). A scoring system, derived from selected parameters, significantly differentiated children with AHO on the basis of causative organism, intensive care admission, surgeries, length of hospitalization, complications and physician panel assessment. CONCLUSIONS: Severity of illness score for AHO, derived from preliminary clinical and laboratory findings, is useful stratifying children with this disease. Level of Evidence: Prognostic Level II

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalPediatric Infectious Disease Journal
Volume33
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Osteomyelitis
Pediatrics
Hospitalization
Critical Care
Anti-Bacterial Agents
Physicians
Fever
Respiratory Rate
Ambulatory Surgical Procedures
Intubation
Venous Thrombosis
C-Reactive Protein
Length of Stay
Lung
Infection

Keywords

  • Osteomyelitis
  • Pediatric
  • Scoring System
  • Severity Of Illness
  • Staphylococcus Aureus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

A proposed scoring system for assessment of severity of illness in pediatric acute hematogenous osteomyelitis using objective clinical and laboratory findings. / Copley, Lawson A B; Barton, Theresa; Garcia, Carla; Sun, David; Gaviria-Agudelo, Claudia; Gheen, William T.; Browne, Richard H.

In: Pediatric Infectious Disease Journal, Vol. 33, No. 1, 01.2014, p. 35-41.

Research output: Contribution to journalArticle

Copley, Lawson A B ; Barton, Theresa ; Garcia, Carla ; Sun, David ; Gaviria-Agudelo, Claudia ; Gheen, William T. ; Browne, Richard H. / A proposed scoring system for assessment of severity of illness in pediatric acute hematogenous osteomyelitis using objective clinical and laboratory findings. In: Pediatric Infectious Disease Journal. 2014 ; Vol. 33, No. 1. pp. 35-41.
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