Objective: To analyze prospectively the impact of age at diagnosis in childhood idiopathic thrombocytopenic purpura (ITP). Study design: International registry from June 1997 to May 2001, with analysis of data from baseline and 6-month-follow-up questionnaires. Results: Data from 2540 patients were analyzed, including 203 infants (7.6%), 1860 children ≥1 to <10 years of age (69.1%), and 477 children and adolescents between ≥10 and <16 years of age (17.7%). The mean platelet count at diagnosis was similar in all three groups, as was the percentage of patients with initial platelet count <20 × 109/L. The male/female ratio was highest in infants and decreased with age (P = .009). Immunoglobulin therapy was used more often in infants and corticosteroids in patients ≥10 years of age. Follow-up information at 6 months was available for 1742 children (68.6%). Chronic ITP was seen less frequently in infants (23.1%) than in children >10 years of age (47.3%, P < .0001). Intracranial hemorrhage occurred in 3 of 1742 children during the first 6 months after the diagnosis of ITP. Conclusions: Pediatric patients with ITP from infancy to adolescence exhibit heterogeneity in clinical, demographic, and treatment factors.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health