A prospective postoperative evaluation of urinary tumor‐associated antigens in sarcoma patients. Correlation with disease recurrence

J. F. Huth, R. K. Gupta, F. R. Eilber, D. L. Morton

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Tumor‐associated antigens (TAA) excreted into the urine of sarcoma patients can be detected by the complement‐fixation assay. The authors prospectively measured TAA levels in the urine of 50 sarcoma patients postoperatively to determine whether reappearance of antigen in the urine would be predictive of disease recurrence. Twenty‐five patients developed recurrence of their disease in the postoperative period, and 24 (96%) had reappearance of antigen in the urine 10.1 ± 9.2 months prior to clinical evidence of recurrence. Of the 25 patients who remained disease free (mean follow‐up, 48 months), 23 of 25 (92%) were urinary‐antigen negative at last follow‐up, although 8 patients had transient elevations of urinary TAA early in the postoperative period. Results indicate that postoperative measurement of urinary TAA in sarcoma patients permits selection of a subset of individuals at high risk for the development of recurrence. This knowledge can be of assistance in the postoperative management of these patients. Cancer 53:1306‐1310, 1984.

Original languageEnglish (US)
Pages (from-to)1306-1310
Number of pages5
JournalCancer
Volume53
Issue number6
DOIs
StatePublished - Mar 15 1984

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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