A prospective study of angiotensin II pressor responsiveness in pregnancies complicated by chronic essential hypertension

N. F. Gant, J. M. Jimenez, P. J. Whalley, S. Chand, P. C. MacDonald

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The present study was designed to (1) outline, in a prospective manner, vascular responsiveness to angiotensin II (A-II) in gravidas with essential hypertension and (2) ascertain if increased sensitivity to infused A-II could be detected before worsening of hypertension developed in those women who were destined to develop superimposed pregnancy-induced hypertension (PIH). Sixty-three women with chronic essential hypertension were studied sequentially throughout pregnancy and two groups of patients were defined on the basis of clinical outcome and serial measurements of vascular reactivity to exogenenously administered A-II. The first group consisted of 29 gravidas with chronic hypertension alone and the second group was composed of 34 patients with chronic hypertension who were destined to develop superimposed PIH. Vascular resistance to infused A-II (more than 7 ng. per kilograms per minute required to increase diastolic blood pressure 20 mm. Hg) was observed from weeks 21 to 27 of gestation in both groups of patients. In the gravidas with essential hypertension alone, resistance to A-II persisted throughout the remainder of pregnancy. However, in those women destined to develop PIH, an increased sensitivity to A-II developed after week 27 of gestation and the differences in mean values between the two groups of patients became highly significant after week 30 of gestation (P < 0.025). Although individual determinations obtained in both groups of patients between weeks 28 and 32 of pregnancy suggested that pressor responsiveness to A-II might be used as a screening technique to identify those women destined to develop PIH, additional studies conducted between weeks 28 and 32 of gestation will be required before the efficacy of such a screening technique is clearly established.

Original languageEnglish (US)
Pages (from-to)369-375
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume127
Issue number4
StatePublished - Feb 15 1977

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Angiotensin II
Pregnancy Induced Hypertension
Prospective Studies
Pregnancy
Hypertension
Blood Vessels
Blood Pressure
Essential Hypertension
Vascular Resistance

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

A prospective study of angiotensin II pressor responsiveness in pregnancies complicated by chronic essential hypertension. / Gant, N. F.; Jimenez, J. M.; Whalley, P. J.; Chand, S.; MacDonald, P. C.

In: American Journal of Obstetrics and Gynecology, Vol. 127, No. 4, 15.02.1977, p. 369-375.

Research output: Contribution to journalArticle

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