A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Philipp Hubel, Christian Urban, Valter Bergant, William M. Schneider, Barbara Knauer, Alexey Stukalov, Pietro Scaturro, Angelika Mann, Linda Brunotte, Heinrich H. Hoffmann, John W Schoggins, Martin Schwemmle, Matthias Mann, Charles M. Rice, Andreas Pichlmair

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.

Original languageEnglish (US)
JournalNature Immunology
DOIs
StatePublished - Jan 1 2019

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Protein Interaction Maps
Interferons
Immune System
Gene Regulatory Networks
Genes
Virus Diseases
Interferon-gamma
Immunity
Mass Spectrometry

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hubel, P., Urban, C., Bergant, V., Schneider, W. M., Knauer, B., Stukalov, A., ... Pichlmair, A. (2019). A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature Immunology. https://doi.org/10.1038/s41590-019-0323-3

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. / Hubel, Philipp; Urban, Christian; Bergant, Valter; Schneider, William M.; Knauer, Barbara; Stukalov, Alexey; Scaturro, Pietro; Mann, Angelika; Brunotte, Linda; Hoffmann, Heinrich H.; Schoggins, John W; Schwemmle, Martin; Mann, Matthias; Rice, Charles M.; Pichlmair, Andreas.

In: Nature Immunology, 01.01.2019.

Research output: Contribution to journalArticle

Hubel, P, Urban, C, Bergant, V, Schneider, WM, Knauer, B, Stukalov, A, Scaturro, P, Mann, A, Brunotte, L, Hoffmann, HH, Schoggins, JW, Schwemmle, M, Mann, M, Rice, CM & Pichlmair, A 2019, 'A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape', Nature Immunology. https://doi.org/10.1038/s41590-019-0323-3
Hubel, Philipp ; Urban, Christian ; Bergant, Valter ; Schneider, William M. ; Knauer, Barbara ; Stukalov, Alexey ; Scaturro, Pietro ; Mann, Angelika ; Brunotte, Linda ; Hoffmann, Heinrich H. ; Schoggins, John W ; Schwemmle, Martin ; Mann, Matthias ; Rice, Charles M. ; Pichlmair, Andreas. / A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. In: Nature Immunology. 2019.
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