A radioimmunoassay for plasma aldosterone by immunologic purification

C. Gomez-Sanchez; D. C. Kem; Norman M Kaplan

doi:10.1210/jcem-36-4-795

A radioimmunoassay for plasma aldosterone by immunologic purification

C. Gomez-Sanchez, D. C. Kem, Norman M Kaplan

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

A method for measuring aldosterone concentration has been improved by extracting the steroid from plasma with an antibody prior to radioimmunoassay. Precision, sensitivity and specificity were comparable in our laboratory to a method using paper chormatography and to published data for other methods. Duplicate specimens assayed with both methods gave a correlation of r = 0.91 (p < 0.005). This method eliminates chromatography and enables one technician to process 80-120 specimens each week.

Original language	English (US)
Pages (from-to)	795-798
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	36
Issue number	4
DOIs	https://doi.org/10.1210/jcem-36-4-795
State	Published - Apr 1973

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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A radioimmunoassay for plasma aldosterone by immunologic purification

Abstract

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