A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: Case report and review of literature

Inna V. Fedorenko; Brittany Evernden; Rajappa S. Kenchappa; Solmaz Sahebjam; Elena Ryzhova; John Puskas; Linda McIntosh; Gisela Caceres; Anthony Magliocco; Arnold Etame; J. William Harbour; Keiran S.M. Smalley; Peter A. Forsyth

doi:10.1097/CMR.0000000000000274

A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: Case report and review of literature

Inna V. Fedorenko, Brittany Evernden, Rajappa S. Kenchappa, Solmaz Sahebjam, Elena Ryzhova, John Puskas, Linda McIntosh, Gisela Caceres, Anthony Magliocco, Arnold Etame, J. William Harbour, Keiran S.M. Smalley, Peter A. Forsyth

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Uveal melanoma is a rare subtype of melanoma, accounting for only 3-5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

Original language	English (US)
Pages (from-to)	481-486
Number of pages	6
Journal	Melanoma research
Volume	26
Issue number	5
DOIs	https://doi.org/10.1097/CMR.0000000000000274
State	Published - 2016
Externally published	Yes

Keywords

circulating tumor cells
leptomeningeal carcinomatosis
metastasis
uveal melanoma

ASJC Scopus subject areas

Oncology
Dermatology
Cancer Research

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10.1097/CMR.0000000000000274

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Fedorenko, I. V., Evernden, B., Kenchappa, R. S., Sahebjam, S., Ryzhova, E., Puskas, J., McIntosh, L., Caceres, G., Magliocco, A., Etame, A., Harbour, J. W., Smalley, K. S. M., & Forsyth, P. A. (2016). A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: Case report and review of literature. Melanoma research, 26(5), 481-486. https://doi.org/10.1097/CMR.0000000000000274

Fedorenko, IV, Evernden, B, Kenchappa, RS, Sahebjam, S, Ryzhova, E, Puskas, J, McIntosh, L, Caceres, G, Magliocco, A, Etame, A, Harbour, JW, Smalley, KSM & Forsyth, PA 2016, 'A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: Case report and review of literature', Melanoma research, vol. 26, no. 5, pp. 481-486. https://doi.org/10.1097/CMR.0000000000000274

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title = "A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: Case report and review of literature",

abstract = "Uveal melanoma is a rare subtype of melanoma, accounting for only 3-5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.",

keywords = "circulating tumor cells, leptomeningeal carcinomatosis, metastasis, uveal melanoma",

author = "Fedorenko, {Inna V.} and Brittany Evernden and Kenchappa, {Rajappa S.} and Solmaz Sahebjam and Elena Ryzhova and John Puskas and Linda McIntosh and Gisela Caceres and Anthony Magliocco and Arnold Etame and Harbour, {J. William} and Smalley, {Keiran S.M.} and Forsyth, {Peter A.}",

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year = "2016",

doi = "10.1097/CMR.0000000000000274",

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AU - Kenchappa, Rajappa S.

AU - Sahebjam, Solmaz

AU - Ryzhova, Elena

AU - Puskas, John

AU - McIntosh, Linda

AU - Caceres, Gisela

AU - Magliocco, Anthony

AU - Etame, Arnold

AU - Harbour, J. William

AU - Smalley, Keiran S.M.

AU - Forsyth, Peter A.

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AB - Uveal melanoma is a rare subtype of melanoma, accounting for only 3-5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

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KW - leptomeningeal carcinomatosis

KW - metastasis

KW - uveal melanoma

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A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: Case report and review of literature

Abstract

Keywords

ASJC Scopus subject areas

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