A Receptor‐Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture)

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Abstract

How does the healthy organism regulate cholesterol metabolism? The answer to this question was obtained, inter alia, by studies on patients with a genetic disease, familial hypercholesterolemia. Michael S. Brown and Joseph L. Goldstein recognized thereby the key role of the receptor for the cholesterol‐transport protein LDL. The receptor is a well‐characterized protein; studies afforded insights into endocytosis and the pathway by which the receptors enter and leave the cell. Genetic defects in the LDL receptors give rise to an accumulation of cholesterol in plasma and premature arteriosclerosis.

Original languageEnglish (US)
Pages (from-to)583-602
Number of pages20
JournalAngewandte Chemie - International Edition
Volume25
Issue number7
DOIs
StatePublished - 1986

Keywords

  • Catalysis
  • Cholesterol homeostasis
  • Nobel lecture
  • Receptors

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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