A retrospective analysis of tumor volumetric responses to five-fraction stereotactic radiotherapy for paragangliomas of the head and neck (Glomus tumors)

Stephen G. Chun, Lucien A. Nedzi, Kevin S. Choe, Ramzi E. Abdulrahman, Susie A. Chen, John S. Yordy, Robert D. Timmerman, Joe W. Kutz, Brandon Isaacson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Skull base paragangliomas (SBP) are locally expansile tumors that can be treated with stereotactic radiotherapy with favorable results. This report describes the results of 31 patients with SBP treated with CyberKnife radiotherapy delivering a total dose of 25 Gray in five fractions. Methods: All patients treated with five-fraction CyberKnife radiotherapy at a single institution were identified between 2007 and 2013. Tumor volumetric analyses were performed to assess responses to radiotherapy. Results: Median follow-up was 24 months with a range of 4-78 months. Local control and overall survival were 100%. Of the 20 patients who presented with tinnitus, 12 reported improvement (60%), of whom 6 reported complete resolution. There was a 37.3% reduction in tumor volume among all patients (p = 0.16). On subset analysis of patients with ≥24 months of follow-up, tumor volume decreased 49% (p = 0.01). The rate of grade 1-2 toxicity was 19%, with no grade 3 or worse toxicity. Conclusion: A five-fraction CyberKnife-based stereotactic radiotherapy approach is safe and efficacious for the management for patients with SBP. Our findings suggest the potential use of this strategy as a definitive or salvage treatment option for SBP.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalStereotactic and Functional Neurosurgery
Volume92
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Glomus Tumor
Paraganglioma
Neck
Radiotherapy
Head
Skull Base
Neoplasms
Tumor Burden
Salvage Therapy
Tinnitus
Survival

Keywords

  • CyberKnife
  • Glomus jugulare
  • Glomus jugulotympanicum
  • Glomus tumor
  • Paraganglioma
  • Radiation therapy
  • Stereotactic body radiation therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

@article{762088a15724414d881848ac8b68cff0,
title = "A retrospective analysis of tumor volumetric responses to five-fraction stereotactic radiotherapy for paragangliomas of the head and neck (Glomus tumors)",
abstract = "Background: Skull base paragangliomas (SBP) are locally expansile tumors that can be treated with stereotactic radiotherapy with favorable results. This report describes the results of 31 patients with SBP treated with CyberKnife radiotherapy delivering a total dose of 25 Gray in five fractions. Methods: All patients treated with five-fraction CyberKnife radiotherapy at a single institution were identified between 2007 and 2013. Tumor volumetric analyses were performed to assess responses to radiotherapy. Results: Median follow-up was 24 months with a range of 4-78 months. Local control and overall survival were 100{\%}. Of the 20 patients who presented with tinnitus, 12 reported improvement (60{\%}), of whom 6 reported complete resolution. There was a 37.3{\%} reduction in tumor volume among all patients (p = 0.16). On subset analysis of patients with ≥24 months of follow-up, tumor volume decreased 49{\%} (p = 0.01). The rate of grade 1-2 toxicity was 19{\%}, with no grade 3 or worse toxicity. Conclusion: A five-fraction CyberKnife-based stereotactic radiotherapy approach is safe and efficacious for the management for patients with SBP. Our findings suggest the potential use of this strategy as a definitive or salvage treatment option for SBP.",
keywords = "CyberKnife, Glomus jugulare, Glomus jugulotympanicum, Glomus tumor, Paraganglioma, Radiation therapy, Stereotactic body radiation therapy",
author = "Chun, {Stephen G.} and Nedzi, {Lucien A.} and Choe, {Kevin S.} and Abdulrahman, {Ramzi E.} and Chen, {Susie A.} and Yordy, {John S.} and Timmerman, {Robert D.} and Kutz, {Joe W.} and Brandon Isaacson",
year = "2014",
doi = "10.1159/000360864",
language = "English (US)",
volume = "92",
pages = "153--159",
journal = "Stereotactic and Functional Neurosurgery",
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}

TY - JOUR

T1 - A retrospective analysis of tumor volumetric responses to five-fraction stereotactic radiotherapy for paragangliomas of the head and neck (Glomus tumors)

AU - Chun, Stephen G.

AU - Nedzi, Lucien A.

AU - Choe, Kevin S.

AU - Abdulrahman, Ramzi E.

AU - Chen, Susie A.

AU - Yordy, John S.

AU - Timmerman, Robert D.

AU - Kutz, Joe W.

AU - Isaacson, Brandon

PY - 2014

Y1 - 2014

N2 - Background: Skull base paragangliomas (SBP) are locally expansile tumors that can be treated with stereotactic radiotherapy with favorable results. This report describes the results of 31 patients with SBP treated with CyberKnife radiotherapy delivering a total dose of 25 Gray in five fractions. Methods: All patients treated with five-fraction CyberKnife radiotherapy at a single institution were identified between 2007 and 2013. Tumor volumetric analyses were performed to assess responses to radiotherapy. Results: Median follow-up was 24 months with a range of 4-78 months. Local control and overall survival were 100%. Of the 20 patients who presented with tinnitus, 12 reported improvement (60%), of whom 6 reported complete resolution. There was a 37.3% reduction in tumor volume among all patients (p = 0.16). On subset analysis of patients with ≥24 months of follow-up, tumor volume decreased 49% (p = 0.01). The rate of grade 1-2 toxicity was 19%, with no grade 3 or worse toxicity. Conclusion: A five-fraction CyberKnife-based stereotactic radiotherapy approach is safe and efficacious for the management for patients with SBP. Our findings suggest the potential use of this strategy as a definitive or salvage treatment option for SBP.

AB - Background: Skull base paragangliomas (SBP) are locally expansile tumors that can be treated with stereotactic radiotherapy with favorable results. This report describes the results of 31 patients with SBP treated with CyberKnife radiotherapy delivering a total dose of 25 Gray in five fractions. Methods: All patients treated with five-fraction CyberKnife radiotherapy at a single institution were identified between 2007 and 2013. Tumor volumetric analyses were performed to assess responses to radiotherapy. Results: Median follow-up was 24 months with a range of 4-78 months. Local control and overall survival were 100%. Of the 20 patients who presented with tinnitus, 12 reported improvement (60%), of whom 6 reported complete resolution. There was a 37.3% reduction in tumor volume among all patients (p = 0.16). On subset analysis of patients with ≥24 months of follow-up, tumor volume decreased 49% (p = 0.01). The rate of grade 1-2 toxicity was 19%, with no grade 3 or worse toxicity. Conclusion: A five-fraction CyberKnife-based stereotactic radiotherapy approach is safe and efficacious for the management for patients with SBP. Our findings suggest the potential use of this strategy as a definitive or salvage treatment option for SBP.

KW - CyberKnife

KW - Glomus jugulare

KW - Glomus jugulotympanicum

KW - Glomus tumor

KW - Paraganglioma

KW - Radiation therapy

KW - Stereotactic body radiation therapy

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