A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host

Jiarong Gao, Ning Yang, Fred A. Lewis, Peter Yau, James J. Collins, Jonathan V. Sweedler, Phillip A. Newmark

Research output: Contribution to journalArticle

Abstract

Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection.

Original languageEnglish (US)
Pages (from-to)e3000485
JournalPLoS biology
Volume17
Issue number10
DOIs
StatePublished - Oct 1 2019

Fingerprint

schistosomiasis
Schistosoma
Schistosomiasis
Rotifera
Cercaria
Praziquantel
cercariae
Paralysis
Infection
Alkaloids
Pharmaceutical Preparations
Purification
Life cycle
infection
Molecules
Platyhelminths
Water
Neglected Diseases
Snails
praziquantel

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host. / Gao, Jiarong; Yang, Ning; Lewis, Fred A.; Yau, Peter; Collins, James J.; Sweedler, Jonathan V.; Newmark, Phillip A.

In: PLoS biology, Vol. 17, No. 10, 01.10.2019, p. e3000485.

Research output: Contribution to journalArticle

Gao, Jiarong ; Yang, Ning ; Lewis, Fred A. ; Yau, Peter ; Collins, James J. ; Sweedler, Jonathan V. ; Newmark, Phillip A. / A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host. In: PLoS biology. 2019 ; Vol. 17, No. 10. pp. e3000485.
@article{e07ed03ad85d4963b5e37188d665abcd,
title = "A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host",
abstract = "Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection.",
author = "Jiarong Gao and Ning Yang and Lewis, {Fred A.} and Peter Yau and Collins, {James J.} and Sweedler, {Jonathan V.} and Newmark, {Phillip A.}",
year = "2019",
month = "10",
day = "1",
doi = "10.1371/journal.pbio.3000485",
language = "English (US)",
volume = "17",
pages = "e3000485",
journal = "PLoS Biology",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "10",

}

TY - JOUR

T1 - A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host

AU - Gao, Jiarong

AU - Yang, Ning

AU - Lewis, Fred A.

AU - Yau, Peter

AU - Collins, James J.

AU - Sweedler, Jonathan V.

AU - Newmark, Phillip A.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection.

AB - Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection.

UR - http://www.scopus.com/inward/record.url?scp=85073509579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073509579&partnerID=8YFLogxK

U2 - 10.1371/journal.pbio.3000485

DO - 10.1371/journal.pbio.3000485

M3 - Article

C2 - 31622335

AN - SCOPUS:85073509579

VL - 17

SP - e3000485

JO - PLoS Biology

JF - PLoS Biology

SN - 1544-9173

IS - 10

ER -