A second generation MRI contrast agent for imaging zinc ions in vivo

Luis M. De León-Rodríguez, Angelo J M Lubag, Jorge A. López, Gabriel Andreu-De-Riquer, José C. Alvarado-Monzón, A. Dean Sherry

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A Zn 2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn 2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn 2+.

Original languageEnglish (US)
Pages (from-to)480-483
Number of pages4
JournalMedChemComm
Volume3
Issue number4
DOIs
StatePublished - Apr 1 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    De León-Rodríguez, L. M., Lubag, A. J. M., López, J. A., Andreu-De-Riquer, G., Alvarado-Monzón, J. C., & Sherry, A. D. (2012). A second generation MRI contrast agent for imaging zinc ions in vivo. MedChemComm, 3(4), 480-483. https://doi.org/10.1039/c2md00301e