Abstract
Norovirus is an enteric virus that infects intestinal epithelial tuft cells in mice. Lee et al. discover that murine norovirus NS1 is an unconventionally secreted protein that overcomes IFN-λ-mediated norovirus control and is critical for intestinal infection in mice. Additionally, vaccination with NS1 alone confers protection, suggesting potential vaccine strategies.
Original language | English (US) |
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Pages (from-to) | 845-857.e5 |
Journal | Cell Host and Microbe |
Volume | 25 |
Issue number | 6 |
DOIs | |
State | Published - Jun 12 2019 |
Keywords
- IFN-λ
- NS1
- norovirus
- secretion
- vaccine
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology