A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Sanghyun Lee, Hejun Liu, Craig B. Wilen, Zoi E. Sychev, Chandni Desai, Barry L. Hykes, Robert C. Orchard, Broc T. McCune, Ki Wook Kim, Timothy J. Nice, Scott A. Handley, Megan T. Baldridge, Gaya K. Amarasinghe, Herbert W. Virgin

Research output: Contribution to journalArticle

6 Scopus citations


Norovirus is an enteric virus that infects intestinal epithelial tuft cells in mice. Lee et al. discover that murine norovirus NS1 is an unconventionally secreted protein that overcomes IFN-λ-mediated norovirus control and is critical for intestinal infection in mice. Additionally, vaccination with NS1 alone confers protection, suggesting potential vaccine strategies.

Original languageEnglish (US)
Pages (from-to)845-857.e5
JournalCell Host and Microbe
Issue number6
StatePublished - Jun 12 2019



  • IFN-λ
  • norovirus
  • NS1
  • secretion
  • vaccine

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Lee, S., Liu, H., Wilen, C. B., Sychev, Z. E., Desai, C., Hykes, B. L., Orchard, R. C., McCune, B. T., Kim, K. W., Nice, T. J., Handley, S. A., Baldridge, M. T., Amarasinghe, G. K., & Virgin, H. W. (2019). A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell Host and Microbe, 25(6), 845-857.e5. https://doi.org/10.1016/j.chom.2019.04.005